PDB entry 4hco

View 4hco on RCSB PDB site
Description: Human Plk1-PBD in complex with Thymoquinone at the phophopeptide binding site
Class: transferase/transferase inhibitor
Keywords: Kinase, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2012-10-01, released 2012-10-10
The last revision prior to the SCOPe 2.03 freeze date was dated 2013-03-06, with a file datestamp of 2013-03-01.
Experiment type: XRAY
Resolution: 2.75 Å
R-factor: 0.21
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Serine/threonine-protein kinase PLK1
    Species: Homo sapiens [TaxId:9606]
    Gene: PLK1, PLK
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d4hcoa1, d4hcoa2
  • Chain 'B':
    Compound: Serine/threonine-protein kinase PLK1
    Species: Homo sapiens [TaxId:9606]
    Gene: PLK1, PLK
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d4hcob1, d4hcob2
  • Heterogens: GOL, IMW, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4hcoA (A:)
snagevvdchlsdmlqqlhsvnaskpserglvrqeeaedpacipifwvskwvdysdkygl
gyqlcdnsvgvlfndstrlilyndgdslqyierdgtesyltvsshpnslmkkitllkyfr
nymsehllkaganitpregdelarlpylrtwfrtrsaiilhlsngsvqinffqdhtklil
cplmaavtyidekrdfrtyrlslleeygcckelasrlryartmvdkllssrsasnrlkas

    Sequence, based on observed residues (ATOM records): (download) 
    >4hcoA (A:)
hlsdmlqqlhsvnaskpserglvrqeeaedpacipifwvskwvdysdkyglgyqlcdnsv
gvlfndstrlilyndgdslqyierdgtesyltvsshpnslmkkitllkyfrnymsehllk
aganitpregdlarlpylrtwfrtrsaiilhlsngsvqinffqdhtklilcplmaavtyi
dekrdfrtyrlslleeygcckelasrlryartmvdkllss

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4hcoB (B:)
snagevvdchlsdmlqqlhsvnaskpserglvrqeeaedpacipifwvskwvdysdkygl
gyqlcdnsvgvlfndstrlilyndgdslqyierdgtesyltvsshpnslmkkitllkyfr
nymsehllkaganitpregdelarlpylrtwfrtrsaiilhlsngsvqinffqdhtklil
cplmaavtyidekrdfrtyrlslleeygcckelasrlryartmvdkllssrsasnrlkas

    Sequence, based on observed residues (ATOM records): (download) 
    >4hcoB (B:)
dchlsdmlqqlhsvnaskpserglvrqeeaedpacipifwvskwvdysdkyglgyqlcdn
svgvlfndstrlilyndgdslqyierdgtesyltvsshpnslmkkitllkyfrnymsehl
lkaganitprlarlpylrtwfrtrsaiilhlsngsvqinffqdhtklilcplmaavtyid
ekrdfrtyrlslleeygcckelasrlryartmvdkllssr