PDB entry 4hbm

View 4hbm on RCSB PDB site
Description: Ordering of the N Terminus of Human MDM2 by Small Molecule Inhibitors
Class: ligase/ligase inhibitor
Keywords: MDM2, p53, protein protein interaction, inhibitor, ligase-ligase inhibitor complex
Deposited on 2012-09-28, released 2012-10-17
The last revision prior to the SCOPe 2.03 freeze date was dated 2013-01-02, with a file datestamp of 2012-12-28.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: 0.22
AEROSPACI score: 0.44 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: E3 ubiquitin-protein ligase Mdm2
    Species: Homo sapiens [TaxId:9606]
    Gene: MDM2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d4hbma_
  • Chain 'B':
    Compound: E3 ubiquitin-protein ligase Mdm2
    Species: Homo sapiens [TaxId:9606]
    Gene: MDM2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d4hbmb_
  • Chain 'C':
    Compound: E3 ubiquitin-protein ligase Mdm2
    Species: Homo sapiens [TaxId:9606]
    Gene: MDM2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d4hbmc_
  • Chain 'D':
    Compound: E3 ubiquitin-protein ligase Mdm2
    Species: Homo sapiens [TaxId:9606]
    Gene: MDM2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d4hbmd_
  • Chain 'E':
    Compound: E3 ubiquitin-protein ligase Mdm2
    Species: Homo sapiens [TaxId:9606]
    Gene: MDM2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d4hbme_
  • Chain 'F':
    Compound: E3 ubiquitin-protein ligase Mdm2
    Species: Homo sapiens [TaxId:9606]
    Gene: MDM2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d4hbmf_
  • Chain 'G':
    Compound: E3 ubiquitin-protein ligase Mdm2
    Species: Homo sapiens [TaxId:9606]
    Gene: MDM2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d4hbmg_
  • Chain 'H':
    Compound: E3 ubiquitin-protein ligase Mdm2
    Species: Homo sapiens [TaxId:9606]
    Gene: MDM2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d4hbmh_
  • Heterogens: 0Y7, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4hbmA (A:)
msvptdgavttsqipaseqetlvrpkplllkllksvgaqkdtytmkevlfylgqyimtkr
lydekqqhivycsndllgdlfgvpsfsvkehrkiytmiyrnlvvvnqqessdsgtsvsen

    Sequence, based on observed residues (ATOM records): (download) 
    >4hbmA (A:)
msvptdgavttsqipaseqetlvrpkplllkllksvgaqkdtytmkevlfylgqyimtkr
lydekqqhivycsndllgdlfgvpsfsvkehrkiytmiyrnlvvvn

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4hbmB (B:)
msvptdgavttsqipaseqetlvrpkplllkllksvgaqkdtytmkevlfylgqyimtkr
lydekqqhivycsndllgdlfgvpsfsvkehrkiytmiyrnlvvvnqqessdsgtsvsen

    Sequence, based on observed residues (ATOM records): (download) 
    >4hbmB (B:)
vptdgavttsqipaseqetlvrpkplllkllksvgaqkdtytmkevlfylgqyimtkrly
dekqqhivycsndllgdlfgvpsfsvkehrkiytmiyrnlvvvn

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4hbmC (C:)
msvptdgavttsqipaseqetlvrpkplllkllksvgaqkdtytmkevlfylgqyimtkr
lydekqqhivycsndllgdlfgvpsfsvkehrkiytmiyrnlvvvnqqessdsgtsvsen

    Sequence, based on observed residues (ATOM records): (download) 
    >4hbmC (C:)
vptdgavttsqipaseqetlvrpkplllkllksvgaqkdtytmkevlfylgqyimtkrly
dekqqhivycsndllgdlfgvpsfsvkehrkiytmiyrnlvvvn

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4hbmD (D:)
msvptdgavttsqipaseqetlvrpkplllkllksvgaqkdtytmkevlfylgqyimtkr
lydekqqhivycsndllgdlfgvpsfsvkehrkiytmiyrnlvvvnqqessdsgtsvsen

    Sequence, based on observed residues (ATOM records): (download) 
    >4hbmD (D:)
svptdgavttsqipaseqetlvrpkplllkllksvgaqkdtytmkevlfylgqyimtkrl
yhivycsndllgdlfgvpsfsvkehrkiytmiyrnlvvv

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >4hbmE (E:)
msvptdgavttsqipaseqetlvrpkplllkllksvgaqkdtytmkevlfylgqyimtkr
lydekqqhivycsndllgdlfgvpsfsvkehrkiytmiyrnlvvvnqqessdsgtsvsen

    Sequence, based on observed residues (ATOM records): (download) 
    >4hbmE (E:)
svptdgavttsqipaseqetlvrpkplllkllksvgaqkdtytmkevlfylgqyimtkrl
yqhivycsndllgdlfgvpsfsvkehrkiytmiyrnlvvvn

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >4hbmF (F:)
msvptdgavttsqipaseqetlvrpkplllkllksvgaqkdtytmkevlfylgqyimtkr
lydekqqhivycsndllgdlfgvpsfsvkehrkiytmiyrnlvvvnqqessdsgtsvsen

    Sequence, based on observed residues (ATOM records): (download) 
    >4hbmF (F:)
svptdgavttsqipaseqetlvrpkplllkllksvgaqkdtytmkevlfylgqyimtkrl
yqhivycsndllgdlfgvpsfsvkehrkiytmiyrnlvvvn

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >4hbmG (G:)
msvptdgavttsqipaseqetlvrpkplllkllksvgaqkdtytmkevlfylgqyimtkr
lydekqqhivycsndllgdlfgvpsfsvkehrkiytmiyrnlvvvnqqessdsgtsvsen

    Sequence, based on observed residues (ATOM records): (download) 
    >4hbmG (G:)
svptdgavttsqipaseqetlvrpkplllkllksvgaqkdtytmkevlfylgqyimtkrl
yhivycsndllgdlfgvpsfsvkehrkiytmiyrnlvvvn

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >4hbmH (H:)
msvptdgavttsqipaseqetlvrpkplllkllksvgaqkdtytmkevlfylgqyimtkr
lydekqqhivycsndllgdlfgvpsfsvkehrkiytmiyrnlvvvnqqessdsgtsvsen

    Sequence, based on observed residues (ATOM records): (download) 
    >4hbmH (H:)
vptdgavttsqipaseqetlvrpkplllkllksvgaqkdtytmkevlfylgqyimtkrly
hivycsndllgdlfgvpsfsvkehrkiytmiyrnlvvvn