PDB entry 4haz
View 4haz on RCSB PDB site
Description: Crystal structure of CRM1 inhibitor Leptomycin B in complex with CRM1(R543S,K548E,K579Q)-Ran-RanBP1
Class: protein transport/antibiotic
Keywords: HEAT repeat, nuclear export, Ran-RanBP1, LMB, leptomycin B, PROTEIN TRANSPORT-ANTIBIOTIC complex
Deposited on
2012-09-27, released
2013-01-09
The last revision prior to the SCOPe 2.04 freeze date was dated
2013-02-06, with a file datestamp of
2013-02-01.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: 0.168
AEROSPACI score: 0.51
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: GTP-binding nuclear protein ran
Species: Homo sapiens [TaxId:9606]
Gene: RAN, ARA24, OK/SW-cl.81
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.04: d4haza_ - Chain 'B':
Compound: Ran-specific GTPase-activating protein 1
Species: Saccharomyces cerevisiae [TaxId:4932]
Gene: YRB1, CST20, HTN1, SFO1, YDR002W, YD8119.08
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.04: d4hazb_ - Chain 'C':
Compound: Exportin-1
Species: Saccharomyces cerevisiae [TaxId:4932]
Gene: CRM1, KAP124, XPO1, YGR218W, G8514
Database cross-references and differences (RAF-indexed):
- Uniprot P30822 (2-377)
- Uniprot P30822 (378-End)
- engineered mutation (503)
- engineered mutation (507)
- engineered mutation (512)
- engineered mutation (543)
- engineered mutation (986)
- Heterogens: GNP, MG, CL, LBF, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>4hazA (A:)
maaqgepqvqfklvlvgdggtgkttfvkrhltgefekkyvatlgvevhplvfhtnrgpik
fnvwdtagqekfgglrdgyyiqaqcaiimfdvtsrvtyknvpnwhrdlvrvcenipivlc
gnkvdikdrkvkaksivfhrkknlqyydisaksnynfekpflwlarkligdpnlefvamp
alappevvmdpalaaqyehdlevaqttalpdedddl
Sequence, based on observed residues (ATOM records): (download)
>4hazA (A:)
vqfklvlvgdggtgkttfvkrhltgefekkyvatlgvevhplvfhtnrgpikfnvwdtag
qekfgglrdgyyiqaqcaiimfdvtsrvtyknvpnwhrdlvrvcenipivlcgnkvdikd
rkvkaksivfhrkknlqyydisaksnynfekpflwlarkligdpnlefvampalappeva
aqyehdlevaqttalpdedddl
- Chain 'B':
Sequence, based on SEQRES records: (download)
>4hazB (B:)
dihfepvvhlekvdvktmeedeevlykvraklfrfdkdakewkergtgdckflknkktnk
vrilmrrdktlkicanhiiapeytlkpnvgsdrswvyactadiaegeaeaftfairfgsk
enadkfkeefekaqeinkka
Sequence, based on observed residues (ATOM records): (download)
>4hazB (B:)
eedeevlykvraklfrfdkdakewkergtgdckflknkktnkvrilmrrdktlkicanhi
iapeytlkpnvgsdrswvyactadiaegeaeaftfairfgskenadkfkeefekaqeink
k
- Chain 'C':
No sequence available.