PDB entry 4hax

View 4hax on RCSB PDB site
Description: Crystal structure of CRM1 inhibitor Ratjadone A in complex with CRM1(K579A)-Ran-RanBP1
Class: protein transport/antibiotic
Keywords: HEAT repeat, nuclear export, Ran-RanBP1, Ratjadone A, PROTEIN TRANSPORT-ANTIBIOTIC complex
Deposited on 2012-09-27, released 2013-01-09
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-07-26, with a file datestamp of 2017-07-21.
Experiment type: XRAY
Resolution: 2.28 Å
R-factor: N/A
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: GTP-binding nuclear protein ran
    Species: Homo sapiens [TaxId:9606]
    Gene: RAN, ARA24, OK/SW-cl.81
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4haxa_
  • Chain 'B':
    Compound: Ran-specific GTPase-activating protein 1
    Species: Saccharomyces cerevisiae [TaxId:4932]
    Gene: YRB1, CST20, HTN1, SFO1, YDR002W, YD8119.08
    Database cross-references and differences (RAF-indexed):
    • Uniprot P41920
      • conflict (36)
    Domains in SCOPe 2.08: d4haxb_
  • Chain 'C':
    Compound: Exportin-1
    Species: Saccharomyces cerevisiae [TaxId:4932]
    Gene: CRM1, KAP124, XPO1, YGR218W, G8514
    Database cross-references and differences (RAF-indexed):
    • Uniprot P30822 (2-377)
      • expression tag (0-1)
    • Uniprot P30822 (378-End)
      • engineered mutation (503)
      • engineered mutation (543)
      • engineered mutation (986)
  • Heterogens: RJA, GOL, EDO, CL, GNP, MG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4haxA (A:)
maaqgepqvqfklvlvgdggtgkttfvkrhltgefekkyvatlgvevhplvfhtnrgpik
fnvwdtagqekfgglrdgyyiqaqcaiimfdvtsrvtyknvpnwhrdlvrvcenipivlc
gnkvdikdrkvkaksivfhrkknlqyydisaksnynfekpflwlarkligdpnlefvamp
alappevvmdpalaaqyehdlevaqttalpdedddl

    Sequence, based on observed residues (ATOM records): (download) 
    >4haxA (A:)
qvqfklvlvgdggtgkttfvkrhltgefekkyvatlgvevhplvfhtnrgpikfnvwdta
gqekfgglrdgyyiqaqcaiimfdvtsrvtyknvpnwhrdlvrvcenipivlcgnkvdik
drkvkaksivfhrkknlqyydisaksnynfekpflwlarkligdpnlefvampalappeq
yehdlevaqttalpdedddl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4haxB (B:)
dihfepvvhlekvdvktmeedeevlykvraklfrfdkdakewkergtgdckflknkktnk
vrilmrrdktlkicanhiiapeytlkpnvgsdrswvyactadiaegeaeaftfairfgsk
enadkfkeefekaqeinkka

    Sequence, based on observed residues (ATOM records): (download) 
    >4haxB (B:)
ihfepvvktmeedeevlykvraklfrfdkdakewkergtgdckflknkktnkvrilmrrd
ktlkicanhiiapeytlkpnvgsdrswvyactadiaegeaeaftfairfgskenadkfke
efekaqeinkk

  • Chain 'C':
    No sequence available.