PDB entry 4h8w
View 4h8w on RCSB PDB site
Description: Crystal structure of non-neutralizing and ADCC-potent antibody N5-i5 in complex with HIV-1 clade A/E gp120 and sCD4.
Class: viral protein/immune system
Keywords: HIV-1 GP120, CLADE A/E 93TH057, VIRAL PROTEIN, VIRAL PROTEIN-IMMUNE SYSTEM complex
Deposited on
2012-09-24, released
2014-04-09
The last revision prior to the SCOPe 2.08 freeze date was dated
2020-07-29, with a file datestamp of
2020-07-04.
Experiment type: XRAY
Resolution: 1.85 Å
R-factor: N/A
AEROSPACI score: 0.41
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'C':
Compound: T-cell surface glycoprotein cd4
Species: Homo sapiens [TaxId:9606]
Gene: CD4
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d4h8wc1, d4h8wc2 - Chain 'G':
Compound: hiv-1 clade a/e 93th057 (h375s) gp120
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Chain 'H':
Compound: Fab heavy chain of ADCC and non-neutralizing anti-HIV-1 antibody N5-i5
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d4h8wh_ - Chain 'L':
Compound: Fab light chain of ADCC and non-neutralizing anti-HIV-1 antibody N5-i5
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d4h8wl1, d4h8wl2 - Heterogens: NAG, MRD, GOL, HOH
PDB Chain Sequences:
- Chain 'C':
Sequence, based on SEQRES records: (download)
>4h8wC (C:)
kkvvlgkkgdtveltctasqkksiqfhwknsnqikilgnqgsfltkgpsklndradsrrs
lwdqgnfpliiknlkiedsdtyicevedqkeevqllvfgltansdthllqgqsltltles
ppgsspsvqcrsprgkniqggktlsvsqlelqdsgtwtctvlqnqkkvefkidivvlafq
kasnt
Sequence, based on observed residues (ATOM records): (download)
>4h8wC (C:)
kkvvlgkkgdtveltctasqkksiqfhwknsnqikilgnqgsfltkgpsklndradsrrs
lwdqgnfpliiknlkiedsdtyicevedqkeevqllvfgltansdthllqgqsltltles
ppgsspsvqcrsprgkniqggktlsvsqlelqdsgtwtctvlqnqkkvefkidivv
- Chain 'G':
No sequence available.
- Chain 'H':
Sequence, based on SEQRES records: (download)
>4h8wH (H:)
evqlvesggglvqpggslrlscaasgftfstyamswvrqapgkglewvssinnsgrntfs
adsvkgrftisrdnskntlflvmnslraedtavyycakdlrlgggsdywgqgtlvtvssa
stkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssg
lyslssvvtvpssslgtqtyicnvnhkpsntkvdkrvepkscdkth
Sequence, based on observed residues (ATOM records): (download)
>4h8wH (H:)
evqlvesggglvqpggslrlscaasgftfstyamswvrqapgkglewvssinnsgrntfs
adsvkgrftisrdnskntlflvmnslraedtavyycakdlrlgggsdywgqgtlvtvssa
stkgpsvfplapstaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslssv
vtvpssslgtqtyicnvnhkpsntkvdkrvep
- Chain 'L':
Sequence, based on SEQRES records: (download)
>4h8wL (L:)
qsaltqpasvsgspgqsitisctgtssdvgsynfvswyqqhpgkapklmiyevserpsgi
snrfsgsksgntasltisglqaedeadyycssyagsttfrvfgggtkltvrgqpkaapsv
tlfppsseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaas
sylsltpeqwkshrsyscqvthegstvektvaptecs
Sequence, based on observed residues (ATOM records): (download)
>4h8wL (L:)
saltqpasvsgspgqsitisctgtssdvgsynfvswyqqhpgkapklmiyevserpsgis
nrfsgsksgntasltisglqaedeadyycssyagsttfrvfgggtkltvrgqpkaapsvt
lfppsseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaass
ylsltpeqwkshrsyscqvthegstvektvap