PDB entry 4h81

View 4h81 on RCSB PDB site
Description: Crystal structure of branched-chain alpha-ketoacid dehydrogenase kinase/(R)-2-chloro-3-phenylpropanoic acid complex with ADP
Class: transferase/transferase inhibitor
Keywords: GHKL protein kinase, Allosteric kinase inhibitor, Branched-chain alpha-ketoacid, Branched-chain amino acids, Maple syrup urine disease, Diabetes and obesity, Bergerat nucleotide-binding fold, protein kinase, transferase-transferase inhibitor complex
Deposited on 2012-09-21, released 2013-06-05
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-09-18, with a file datestamp of 2019-09-13.
Experiment type: XRAY
Resolution: 2.05 Å
R-factor: N/A
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial
    Species: Rattus norvegicus [TaxId:10116]
    Gene: Bckdk
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4h81a1, d4h81a2
  • Heterogens: ADP, MG, K, WJ2, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4h81A (A:)
miltsvlgsgprsgsslwpllgsslslrvrstsatdthhvelarersktvtsfynqsaid
vvaekpsvrltptmmlysgrsqdgshllksgrylqqelpvriahrikgfrslpfiigcnp
tilhvhelyirafqkltdfppikdqadeaqycqlvrqllddhkdvvtllaeglresrkhi
edeklvryfldktltsrlgirmlathhlalhedkpdfvgiictrlspkkiiekwvdfarr
lcehkygnaprvringhvaarfpfipmpldyilpellknamratmeshldtpynvpdvvi
tianndvdliirisdrgggiahkdldrvmdyhfttaeastqdprisplfghldmhsggqs
gpmhgfgfglptsrayaeylggslqlqslqgigtdvylrlrhidgreesfrihhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4h81A (A:)
tmmlysgrsqdgshllksgrylqqelpvriahrikgfrslpfiigcnptilhvhelyira
fqkltdfppikdqadeaqycqlvrqllddhkdvvtllaeglresrkhiedeklvryfldk
tltsrlgirmlathhlalhedkpdfvgiictrlspkkiiekwvdfarrlcehkygnaprv
ringhvaarfpfipmpldyilpellknamratmeshldtpynvpdvvitianndvdliir
isdrgggiahkdldrvmdyhfttagfgfglptsrayaeylggslqlqslqgigtdvylrl
rhi