PDB entry 4h73

View 4h73 on RCSB PDB site
Description: Thermostable aldehyde dehydrogenase from Pyrobaculum sp. complexed with NADP+
Class: oxidoreductase
Keywords: Fold, protein, aldehyde oxidation, NADP reduction, Intracellular, cytoplasmic, OXIDOREDUCTASE
Deposited on 2012-09-20, released 2013-10-02
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-01-24, with a file datestamp of 2018-01-19.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: N/A
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: aldehyde dehydrogenase
    Species: Pyrobaculum sp. [TaxId:1104324]
    Gene: P186_1147
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4h73a_
  • Chain 'B':
    Compound: aldehyde dehydrogenase
    Species: Pyrobaculum sp. [TaxId:1104324]
    Gene: P186_1147
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4h73b_
  • Chain 'C':
    Compound: aldehyde dehydrogenase
    Species: Pyrobaculum sp. [TaxId:1104324]
    Gene: P186_1147
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4h73c_
  • Chain 'D':
    Compound: aldehyde dehydrogenase
    Species: Pyrobaculum sp. [TaxId:1104324]
    Gene: P186_1147
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4h73d_
  • Chain 'E':
    Compound: aldehyde dehydrogenase
    Species: Pyrobaculum sp. [TaxId:1104324]
    Gene: P186_1147
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4h73e_
  • Chain 'F':
    Compound: aldehyde dehydrogenase
    Species: Pyrobaculum sp. [TaxId:1104324]
    Gene: P186_1147
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4h73f_
  • Chain 'G':
    Compound: aldehyde dehydrogenase
    Species: Pyrobaculum sp. [TaxId:1104324]
    Gene: P186_1147
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4h73g_
  • Chain 'H':
    Compound: aldehyde dehydrogenase
    Species: Pyrobaculum sp. [TaxId:1104324]
    Gene: P186_1147
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4h73h_
  • Heterogens: NDP, NI, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4h73A (A:)
midlnimkvanyingefkepstgafqvktspvdgskiaevprsgredareaidsafealk
awanipairraeylykmlevfrqmkedfmkiltvegggtyrkvwgevvfterliqnaael
arhyqgrvlqsdsestisvvfkrskgvvgvitpwnyplsismkkiahtlavgntvvykpa
sdtpvtgwliaqmvakaglpkgvfnlvigpgpvvgeeivthkrvahvtftgesstgreia
akaagtlktvtlelggsdpliilddvdvdyaarlavfaslfhqgqictsakriivhkava
dkfieryvhyvkmlriddprkdekvdlgplinerqvalmkefvddavsrggrlliggrsw
gnffepaifvdvdrnfrimreevfgpvrpivvvenddqavevandtdyglsgavltnnvn
rafriaeavesgmfhindvtfleeshvpfggikasgvgreggewsfhettydrwvtvtlr
trrfpipsalk

    Sequence, based on observed residues (ATOM records): (download) 
    >4h73A (A:)
vanyingefkepstgafqvktspvdgskiaevprsgredareaidsafealkawanipai
rraeylykmlevfrqmkedfmkiltvegggtyrkvwgevvfterliqnaaelarhyqgrv
lqsdsestisvvfkrskgvvgvitpwnyplsismkkiahtlavgntvvykpasdtpvtgw
liaqmvakaglpkgvfnlvigpgpvvgeeivthkrvahvtftgesstgreiaakaagtlk
tvtlelggsdpliilddvdvdyaarlavfaslfhqgqictsakriivhkavadkfieryv
hyvkmlriddprkdekvdlgplinerqvalmkefvddavsrggrlliggrswgnffepai
fvdvdrnfrimreevfgpvrpivvvenddqavevandtdyglsgavltnnvnrafriaea
vesgmfhindvtfleeshvpfggikasgvgreggewsfhettydrwvtvtlrtrrfpips
al

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4h73B (B:)
midlnimkvanyingefkepstgafqvktspvdgskiaevprsgredareaidsafealk
awanipairraeylykmlevfrqmkedfmkiltvegggtyrkvwgevvfterliqnaael
arhyqgrvlqsdsestisvvfkrskgvvgvitpwnyplsismkkiahtlavgntvvykpa
sdtpvtgwliaqmvakaglpkgvfnlvigpgpvvgeeivthkrvahvtftgesstgreia
akaagtlktvtlelggsdpliilddvdvdyaarlavfaslfhqgqictsakriivhkava
dkfieryvhyvkmlriddprkdekvdlgplinerqvalmkefvddavsrggrlliggrsw
gnffepaifvdvdrnfrimreevfgpvrpivvvenddqavevandtdyglsgavltnnvn
rafriaeavesgmfhindvtfleeshvpfggikasgvgreggewsfhettydrwvtvtlr
trrfpipsalk

    Sequence, based on observed residues (ATOM records): (download) 
    >4h73B (B:)
mkvanyingefkepstgafqvktspvdgskiaevprsgredareaidsafealkawanip
airraeylykmlevfrqmkedfmkiltvegggtyrkvwgevvfterliqnaaelarhyqg
rvlqsdsestisvvfkrskgvvgvitpwnyplsismkkiahtlavgntvvykpasdtpvt
gwliaqmvakaglpkgvfnlvigpgpvvgeeivthkrvahvtftgesstgreiaakaagt
lktvtlelggsdpliilddvdvdyaarlavfaslfhqgqictsakriivhkavadkfier
yvhyvkmlriddprkdekvdlgplinerqvalmkefvddavsrggrlliggrswgnffep
aifvdvdrnfrimreevfgpvrpivvvenddqavevandtdyglsgavltnnvnrafria
eavesgmfhindvtfleeshvpfggikasgvgreggewsfhettydrwvtvtlrtrrfpi
psalk

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4h73C (C:)
midlnimkvanyingefkepstgafqvktspvdgskiaevprsgredareaidsafealk
awanipairraeylykmlevfrqmkedfmkiltvegggtyrkvwgevvfterliqnaael
arhyqgrvlqsdsestisvvfkrskgvvgvitpwnyplsismkkiahtlavgntvvykpa
sdtpvtgwliaqmvakaglpkgvfnlvigpgpvvgeeivthkrvahvtftgesstgreia
akaagtlktvtlelggsdpliilddvdvdyaarlavfaslfhqgqictsakriivhkava
dkfieryvhyvkmlriddprkdekvdlgplinerqvalmkefvddavsrggrlliggrsw
gnffepaifvdvdrnfrimreevfgpvrpivvvenddqavevandtdyglsgavltnnvn
rafriaeavesgmfhindvtfleeshvpfggikasgvgreggewsfhettydrwvtvtlr
trrfpipsalk

    Sequence, based on observed residues (ATOM records): (download) 
    >4h73C (C:)
mkvanyingefkepstgafqvktspvdgskiaevprsgredareaidsafealkawanip
airraeylykmlevfrqmkedfmkiltvegggtyrkvwgevvfterliqnaaelarhyqg
rvlqsdsestisvvfkrskgvvgvitpwnyplsismkkiahtlavgntvvykpasdtpvt
gwliaqmvakaglpkgvfnlvigpgpvvgeeivthkrvahvtftgesstgreiaakaagt
lktvtlelggsdpliilddvdvdyaarlavfaslfhqgqictsakriivhkavadkfier
yvhyvkmlriddprkdekvdlgplinerqvalmkefvddavsrggrlliggrswgnffep
aifvdvdrnfrimreevfgpvrpivvvenddqavevandtdyglsgavltnnvnrafria
eavesgmfhindvtfleeshvpfggikasgvgreggewsfhettydrwvtvtlrtrrfpi
psalk

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4h73D (D:)
midlnimkvanyingefkepstgafqvktspvdgskiaevprsgredareaidsafealk
awanipairraeylykmlevfrqmkedfmkiltvegggtyrkvwgevvfterliqnaael
arhyqgrvlqsdsestisvvfkrskgvvgvitpwnyplsismkkiahtlavgntvvykpa
sdtpvtgwliaqmvakaglpkgvfnlvigpgpvvgeeivthkrvahvtftgesstgreia
akaagtlktvtlelggsdpliilddvdvdyaarlavfaslfhqgqictsakriivhkava
dkfieryvhyvkmlriddprkdekvdlgplinerqvalmkefvddavsrggrlliggrsw
gnffepaifvdvdrnfrimreevfgpvrpivvvenddqavevandtdyglsgavltnnvn
rafriaeavesgmfhindvtfleeshvpfggikasgvgreggewsfhettydrwvtvtlr
trrfpipsalk

    Sequence, based on observed residues (ATOM records): (download) 
    >4h73D (D:)
mkvanyingefkepstgafqvktspvdgskiaevprsgredareaidsafealkawanip
airraeylykmlevfrqmkedfmkiltvegggtyrkvwgevvfterliqnaaelarhyqg
rvlqsdsestisvvfkrskgvvgvitpwnyplsismkkiahtlavgntvvykpasdtpvt
gwliaqmvakaglpkgvfnlvigpgpvvgeeivthkrvahvtftgesstgreiaakaagt
lktvtlelggsdpliilddvdvdyaarlavfaslfhqgqictsakriivhkavadkfier
yvhyvkmlriddprkdekvdlgplinerqvalmkefvddavsrggrlliggrswgnffep
aifvdvdrnfrimreevfgpvrpivvvenddqavevandtdyglsgavltnnvnrafria
eavesgmfhindvtfleeshvpfggikasgvgreggewsfhettydrwvtvtlrtrrfpi
psalk

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >4h73E (E:)
midlnimkvanyingefkepstgafqvktspvdgskiaevprsgredareaidsafealk
awanipairraeylykmlevfrqmkedfmkiltvegggtyrkvwgevvfterliqnaael
arhyqgrvlqsdsestisvvfkrskgvvgvitpwnyplsismkkiahtlavgntvvykpa
sdtpvtgwliaqmvakaglpkgvfnlvigpgpvvgeeivthkrvahvtftgesstgreia
akaagtlktvtlelggsdpliilddvdvdyaarlavfaslfhqgqictsakriivhkava
dkfieryvhyvkmlriddprkdekvdlgplinerqvalmkefvddavsrggrlliggrsw
gnffepaifvdvdrnfrimreevfgpvrpivvvenddqavevandtdyglsgavltnnvn
rafriaeavesgmfhindvtfleeshvpfggikasgvgreggewsfhettydrwvtvtlr
trrfpipsalk

    Sequence, based on observed residues (ATOM records): (download) 
    >4h73E (E:)
vanyingefkepstgafqvktspvdgskiaevprsgredareaidsafealkawanipai
rraeylykmlevfrqmkedfmkiltvegggtyrkvwgevvfterliqnaaelarhyqgrv
lqsdsestisvvfkrskgvvgvitpwnyplsismkkiahtlavgntvvykpasdtpvtgw
liaqmvakaglpkgvfnlvigpgpvvgeeivthkrvahvtftgesstgreiaakaagtlk
tvtlelggsdpliilddvdvdyaarlavfaslfhqgqictsakriivhkavadkfieryv
hyvkmlriddprkdekvdlgplinerqvalmkefvddavsrggrlliggrswgnffepai
fvdvdrnfrimreevfgpvrpivvvenddqavevandtdyglsgavltnnvnrafriaea
vesgmfhindvtfleeshvpfggikasgvgreggewsfhettydrwvtvtlrtrrfpips
alk

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >4h73F (F:)
midlnimkvanyingefkepstgafqvktspvdgskiaevprsgredareaidsafealk
awanipairraeylykmlevfrqmkedfmkiltvegggtyrkvwgevvfterliqnaael
arhyqgrvlqsdsestisvvfkrskgvvgvitpwnyplsismkkiahtlavgntvvykpa
sdtpvtgwliaqmvakaglpkgvfnlvigpgpvvgeeivthkrvahvtftgesstgreia
akaagtlktvtlelggsdpliilddvdvdyaarlavfaslfhqgqictsakriivhkava
dkfieryvhyvkmlriddprkdekvdlgplinerqvalmkefvddavsrggrlliggrsw
gnffepaifvdvdrnfrimreevfgpvrpivvvenddqavevandtdyglsgavltnnvn
rafriaeavesgmfhindvtfleeshvpfggikasgvgreggewsfhettydrwvtvtlr
trrfpipsalk

    Sequence, based on observed residues (ATOM records): (download) 
    >4h73F (F:)
mkvanyingefkepstgafqvktspvdgskiaevprsgredareaidsafealkawanip
airraeylykmlevfrqmkedfmkiltvegggtyrkvwgevvfterliqnaaelarhyqg
rvlqsdsestisvvfkrskgvvgvitpwnyplsismkkiahtlavgntvvykpasdtpvt
gwliaqmvakaglpkgvfnlvigpgpvvgeeivthkrvahvtftgesstgreiaakaagt
lktvtlelggsdpliilddvdvdyaarlavfaslfhqgqictsakriivhkavadkfier
yvhyvkmlriddprkdekvdlgplinerqvalmkefvddavsrggrlliggrswgnffep
aifvdvdrnfrimreevfgpvrpivvvenddqavevandtdyglsgavltnnvnrafria
eavesgmfhindvtfleeshvpfggikasgvgreggewsfhettydrwvtvtlrtrrfpi
psalk

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >4h73G (G:)
midlnimkvanyingefkepstgafqvktspvdgskiaevprsgredareaidsafealk
awanipairraeylykmlevfrqmkedfmkiltvegggtyrkvwgevvfterliqnaael
arhyqgrvlqsdsestisvvfkrskgvvgvitpwnyplsismkkiahtlavgntvvykpa
sdtpvtgwliaqmvakaglpkgvfnlvigpgpvvgeeivthkrvahvtftgesstgreia
akaagtlktvtlelggsdpliilddvdvdyaarlavfaslfhqgqictsakriivhkava
dkfieryvhyvkmlriddprkdekvdlgplinerqvalmkefvddavsrggrlliggrsw
gnffepaifvdvdrnfrimreevfgpvrpivvvenddqavevandtdyglsgavltnnvn
rafriaeavesgmfhindvtfleeshvpfggikasgvgreggewsfhettydrwvtvtlr
trrfpipsalk

    Sequence, based on observed residues (ATOM records): (download) 
    >4h73G (G:)
kvanyingefkepstgafqvktspvdgskiaevprsgredareaidsafealkawanipa
irraeylykmlevfrqmkedfmkiltvegggtyrkvwgevvfterliqnaaelarhyqgr
vlqsdsestisvvfkrskgvvgvitpwnyplsismkkiahtlavgntvvykpasdtpvtg
wliaqmvakaglpkgvfnlvigpgpvvgeeivthkrvahvtftgesstgreiaakaagtl
ktvtlelggsdpliilddvdvdyaarlavfaslfhqgqictsakriivhkavadkfiery
vhyvkmlriddprkdekvdlgplinerqvalmkefvddavsrggrlliggrswgnffepa
ifvdvdrnfrimreevfgpvrpivvvenddqavevandtdyglsgavltnnvnrafriae
avesgmfhindvtfleeshvpfggikasgvgreggewsfhettydrwvtvtlrtrrfpip
salk

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >4h73H (H:)
midlnimkvanyingefkepstgafqvktspvdgskiaevprsgredareaidsafealk
awanipairraeylykmlevfrqmkedfmkiltvegggtyrkvwgevvfterliqnaael
arhyqgrvlqsdsestisvvfkrskgvvgvitpwnyplsismkkiahtlavgntvvykpa
sdtpvtgwliaqmvakaglpkgvfnlvigpgpvvgeeivthkrvahvtftgesstgreia
akaagtlktvtlelggsdpliilddvdvdyaarlavfaslfhqgqictsakriivhkava
dkfieryvhyvkmlriddprkdekvdlgplinerqvalmkefvddavsrggrlliggrsw
gnffepaifvdvdrnfrimreevfgpvrpivvvenddqavevandtdyglsgavltnnvn
rafriaeavesgmfhindvtfleeshvpfggikasgvgreggewsfhettydrwvtvtlr
trrfpipsalk

    Sequence, based on observed residues (ATOM records): (download) 
    >4h73H (H:)
vanyingefkepstgafqvktspvdgskiaevprsgredareaidsafealkawanipai
rraeylykmlevfrqmkedfmkiltvegggtyrkvwgevvfterliqnaaelarhyqgrv
lqsdsestisvvfkrskgvvgvitpwnyplsismkkiahtlavgntvvykpasdtpvtgw
liaqmvakaglpkgvfnlvigpgpvvgeeivthkrvahvtftgesstgreiaakaagtlk
tvtlelggsdpliilddvdvdyaarlavfaslfhqgqictsakriivhkavadkfieryv
hyvkmlriddprkdekvdlgplinerqvalmkefvddavsrggrlliggrswgnffepai
fvdvdrnfrimreevfgpvrpivvvenddqavevandtdyglsgavltnnvnrafriaea
vesgmfhindvtfleeshvpfggikasgvgreggewsfhettydrwvtvtlrtrrfpips
alk