PDB entry 4h71

View 4h71 on RCSB PDB site
Description: Human Plk1-PBD in complex with Poloxime ((E)-4-(hydroxyimino)-2-isopropyl-5-methylcyclohexa-2,5-dienone)
Class: transferase/transferase inhibitor
Keywords: Kinase, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2012-09-19, released 2012-10-03
The last revision prior to the SCOPe 2.03 freeze date was dated 2013-03-06, with a file datestamp of 2013-03-01.
Experiment type: XRAY
Resolution: 1.93 Å
R-factor: 0.191
AEROSPACI score: 0.47 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Serine/threonine-protein kinase PLK1
    Species: Homo sapiens [TaxId:9606]
    Gene: PLK1, PLK
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d4h71a1, d4h71a2
  • Chain 'B':
    Compound: Serine/threonine-protein kinase PLK1
    Species: Homo sapiens [TaxId:9606]
    Gene: PLK1, PLK
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d4h71b1, d4h71b2
  • Heterogens: GOL, PXE, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4h71A (A:)
snagevvdchlsdmlqqlhsvnaskpserglvrqeeaedpacipifwvskwvdysdkygl
gyqlcdnsvgvlfndstrlilyndgdslqyierdgtesyltvsshpnslmkkitllkyfr
nymsehllkaganitpregdelarlpylrtwfrtrsaiilhlsngsvqinffqdhtklil
cplmaavtyidekrdfrtyrlslleeygcckelasrlryartmvdkllssrsasnrlkas

    Sequence, based on observed residues (ATOM records): (download) 
    >4h71A (A:)
dchlsdmlqqlhsvnaskpserglvrqeeaedpacipifwvskwvdysdkyglgyqlcdn
svgvlfndstrlilyndgdslqyierdgtesyltvsshpnslmkkitllkyfrnymsehl
lkaganitpredelarlpylrtwfrtrsaiilhlsngsvqinffqdhtklilcplmaavt
yidekrdfrtyrlslleeygcckelasrlryartmvdkllss

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4h71B (B:)
snagevvdchlsdmlqqlhsvnaskpserglvrqeeaedpacipifwvskwvdysdkygl
gyqlcdnsvgvlfndstrlilyndgdslqyierdgtesyltvsshpnslmkkitllkyfr
nymsehllkaganitpregdelarlpylrtwfrtrsaiilhlsngsvqinffqdhtklil
cplmaavtyidekrdfrtyrlslleeygcckelasrlryartmvdkllssrsasnrlkas

    Sequence, based on observed residues (ATOM records): (download) 
    >4h71B (B:)
chlsdmlqqlhsvnaskpserglvrqeeaedpacipifwvskwvdysdkyglgyqlcdns
vgvlfndstrlilyndgdslqyierdgtesyltvsshpnslmkkitllkyfrnymsehll
kaganitprrlpylrtwfrtrsaiilhlsngsvqinffqdhtklilcplmaavtyidekr
dfrtyrlslleeygcckelasrlryartmvdkllss