PDB entry 4h5c

View 4h5c on RCSB PDB site
Description: Crystal structure of human FPPS in ternary complex with YS0470 and inorganic phosphate
Class: transferase/transferase inhibitor
Keywords: Transferase, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2012-09-18, released 2012-12-26
The last revision prior to the SCOPe 2.07 freeze date was dated 2012-12-26, with a file datestamp of 2012-12-21.
Experiment type: XRAY
Resolution: 2.02 Å
R-factor: 0.182
AEROSPACI score: 0.48 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'F':
    Compound: farnesyl pyrophosphate synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: FDPS, FPS, KIAA1293
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4h5cf_
  • Heterogens: YS4, PO4, MG, HOH

PDB Chain Sequences:

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >4h5cF (F:)
mgsshhhhhhssgrenlyfqghmngdqnsdvyaqekqdfvqhfsqivrvltedemghpei
gdaiarlkevleynaiggkynrgltvvvafrelveprkqdadslqrawtvgwcvellqaf
flvaddimdssltrrgqicwyqkpgvgldaindanlleaciyrllklycreqpyylnlie
lflqssyqteigqtldlltapqgnvdlvrftekryksivkyktafysfylpiaaamymag
idgekehanakkillemgeffqiqddyldlfgdpsvtgkigtdiqdnkcswlvvqclqra
tpeqyqilkenygqkeaekvarvkalyeeldlpavflqyeedsyshimalieqyaaplpp
avflglarkiykrrk

    Sequence, based on observed residues (ATOM records): (download) 
    >4h5cF (F:)
dvyaqekqdfvqhfsqivrvltedemghpeigdaiarlkevleynaiggkynrgltvvva
frelveprkqdadslqrawtvgwcvellqafflvaddimdssltrrgqicwyqkpgvgld
aindanlleaciyrllklycreqpyylnlielflqssyqteigqtldlltapqgnvdlvr
ftekryksivkyktafysfylpiaaamymagidgekehanakkillemgeffqiqddyld
lfgdpsvtgkigtdiqdnkcswlvvqclqratpeqyqilkenygqkeaekvarvkalyee
ldlpavflqyeedsyshimalieqyaaplppavflglarkiykrrk