PDB entry 4h4o

View 4h4o on RCSB PDB site
Description: Crystal Structure of HIV-1 Reverse Transcriptase (RT) in Complex with (E)-3-(3-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)- 4-fluorophenoxy)-5-fluorophenyl)acrylonitrile (JLJ506), A Non-nucleoside inhibitor
Class: Hydrolase/Hydrolase inhibitor
Keywords: Polymerase, Transferase, Hydrolase/inhibitor, Rnase, Hydrolase-Hydrolase inhibitor complex
Deposited on 2012-09-17, released 2012-12-05
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-11-15, with a file datestamp of 2017-11-10.
Experiment type: XRAY
Resolution: 2.9 Å
R-factor: N/A
AEROSPACI score: 0.16 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Reverse transcriptase/ribonuclease H, Exoribonuclease H, p66 RT
    Species: Human immunodeficiency virus type 1 BH10 [TaxId:11678]
    Gene: p66 RT
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03366 (2-End)
      • expression tag (1)
      • engineered mutation (173-174)
      • engineered mutation (281)
    Domains in SCOPe 2.07: d4h4oa1, d4h4oa2, d4h4oa3
  • Chain 'B':
    Compound: Reverse transcriptase/ribonuclease H, Exoribonuclease H, p51 RT
    Species: Human immunodeficiency virus type 1 [TaxId:11678]
    Gene: p51 RT
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03366 (0-427)
      • engineered mutation (279)
    Domains in SCOPe 2.07: d4h4ob_
  • Heterogens: 506, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4h4oA (A:)
mvpispietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpynt
pvfaikkkdstkwrklvdfrelnkrtqdfwevqlgiphpaglkkkksvtvldvgdayfsv
pldedfrkytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfaaqnpdi
viyqymddlyvgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpdk
wtvqpivlpekdswtvndiqklvgklnwasqiypgikvrqlskllrgtkaltevipltee
aelelaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmr
gahtndvkqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvn
tpplvklwyqlekepivgaetfyvdgaanretklgkagyvtnkgrqkvvpltnttnqkte
lqaiylalqdsglevnivtdsqyalgiiqaqpdkseselvnqiieqlikkekvylawvpa
hkgiggneqvdklvsag

    Sequence, based on observed residues (ATOM records): (download) 
    >4h4oA (A:)
vpispietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntp
vfaikkkdstkwrklvdfrelnkrtqdfwevqlgiphpaglkkkksvtvldvgdayfsvp
ldedfrkytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfaaqnpdiv
iyqymddlyvgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpdkw
tvqpivlpekdswtvndiqklvgklnwasqiypgikvrqlskllrgtkalteviplteea
elelaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrg
ahtndvkqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvnt
pplvklwyqlekepivgaetfyvdgaanretklgkagyvtnkgrqkvvpltnttnqktel
qaiylalqdsglevnivtdsqyalgiiqaqpdkseselvnqiieqlikkekvylawvpah
kgiggneqv

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4h4oB (B:)
pispietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpv
faikkkdstkwrklvdfrelnkrtqdfwevqlgiphpaglkkkksvtvldvgdayfsvpl
dedfrkytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfkkqnpdivi
yqymddlyvgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpdkwt
vqpivlpekdswtvndiqklvgklnwasqiypgikvrqlskllrgtkalteviplteeae
lelaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrga
htndvkqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntp
plvklwyq