PDB entry 4h34

View 4h34 on RCSB PDB site
Description: Crystal structure of the tyrosine phosphatase SHP-2 with Q506P mutation
Class: hydrolase
Keywords: alpha/beta proteins, SH2 domain, phosphatase domain, Tyrosine Phosphatase SHP-2, HYDROLASE
Deposited on 2012-09-13, released 2013-10-02
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-11-15, with a file datestamp of 2017-11-10.
Experiment type: XRAY
Resolution: 2.7 Å
R-factor: N/A
AEROSPACI score: 0.17 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein phosphatase non-receptor type 11
    Species: Homo sapiens [TaxId:9606]
    Gene: PTPN11, PTP2C, SHPTP2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q06124
      • engineered mutation (526)
    Domains in SCOPe 2.07: d4h34a1, d4h34a2, d4h34a3
  • Heterogens: EDO, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4h34A (A:)
mgsshhhhhhssgrenlyfqgmtsrrwfhpnitgveaenllltrgvdgsflarpsksnpg
dftlsvrrngavthikiqntgdyydlyggekfatlaelvqyymehhgqlkekngdvielk
yplncadptserwfhghlsgkeaeklltekgkhgsflvresqshpgdfvlsvrtgddkge
sndgkskvthvmircqelkydvgggerfdsltdlvehykknpmvetlgtvlqlkqplntt
rinaaeiesrvrelsklaettdkvkqgfweefetlqqqeckllysrkegqrqenknknry
knilpfdhtrvvlhdgdpnepvsdyinaniimpefetkcnnskpkksyiatqgclqntvn
dfwrmvfqensrvivmttkevergkskcvkywpdeyalkeygvmrvrnvkesaahdytlr
elklskvgqgntertvwqyhfrtwpdhgvpsdpggvldfleevhhkqesimdagpvvvhc
sagigrtgtfividilidiirekgvdcdidvpktiqmvrsqrsgmvpteaqyrfiymavq
hyietlqrrieeeqkskrkg

    Sequence, based on observed residues (ATOM records): (download) 
    >4h34A (A:)
rrwfhpnitgveaenllltrgvdgsflarpsksnpgdftlsvrrngavthikiqntgdyy
dlyggekfatlaelvqyymehhgqvielkyplncadptserwfhghlsgkeaeklltekg
khgsflvresqshpgdfvlsvrtskvthvmircqelkydvgggerfdsltdlvehykknp
mvetlgtvlqlkqplnttrinaaeiesrvrelskgfweefetlqqqeckllysrkegqrq
enknknryknilpfdhtrvvlhsdyinaniimpefksyiatqgclqntvndfwrmvfqen
srvivmttkevgkskcvkywpdeyalkeygvmrvrnvkesaahdytlrelklskvgqgnt
ertvwqyhfrtwpdhgvpsdpggvldfleevhhkqesimdagpvvvhcsagigrtgtfiv
idilidiirekgvdcdidvpktiqmvrsqrsgmvpteaqyrfiymavqhyietlqrriee
eqkskr