PDB entry 4gwf

View 4gwf on RCSB PDB site
Description: Crystal structure of the tyrosine phosphatase SHP-2 with Y279C mutation
Class: hydrolase
Keywords: alpha/beta proteins, SH2 domain, phosphatase domain, Tyrosine Phosphatase SHP-2, HYDROLASE
Deposited on 2012-09-03, released 2013-09-04
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-11-15, with a file datestamp of 2017-11-10.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: N/A
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein phosphatase non-receptor type 11
    Species: Homo sapiens [TaxId:9606]
    Gene: PTPN11, PTP2C, SHPTP2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q06124
      • engineered mutation (299)
    Domains in SCOPe 2.07: d4gwfa1, d4gwfa2, d4gwfa3
  • Chain 'B':
    Compound: Tyrosine-protein phosphatase non-receptor type 11
    Species: Homo sapiens [TaxId:9606]
    Gene: PTPN11, PTP2C, SHPTP2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q06124
      • engineered mutation (299)
    Domains in SCOPe 2.07: d4gwfb1, d4gwfb2, d4gwfb3
  • Heterogens: EDO, GOL, PEG, PGE, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4gwfA (A:)
mgsshhhhhhssgrenlyfqgmtsrrwfhpnitgveaenllltrgvdgsflarpsksnpg
dftlsvrrngavthikiqntgdyydlyggekfatlaelvqyymehhgqlkekngdvielk
yplncadptserwfhghlsgkeaeklltekgkhgsflvresqshpgdfvlsvrtgddkge
sndgkskvthvmircqelkydvgggerfdsltdlvehykknpmvetlgtvlqlkqplntt
rinaaeiesrvrelsklaettdkvkqgfweefetlqqqeckllysrkegqrqenknknrc
knilpfdhtrvvlhdgdpnepvsdyinaniimpefetkcnnskpkksyiatqgclqntvn
dfwrmvfqensrvivmttkevergkskcvkywpdeyalkeygvmrvrnvkesaahdytlr
elklskvgqgntertvwqyhfrtwpdhgvpsdpggvldfleevhhkqesimdagpvvvhc
sagigrtgtfividilidiirekgvdcdidvpktiqmvrsqrsgmvqteaqyrfiymavq
hyietlqrrieeeqkskrkg

    Sequence, based on observed residues (ATOM records): (download) 
    >4gwfA (A:)
tsrrwfhpnitgveaenllltrgvdgsflarpsnpgdftlsvrrngavthikiqntgdyy
dlyggekfatlaelvqyymegqlkevielkyplncadptserwfhghlsgkeaeklltek
gkhgsflvresqshpgdfvlsvrtgkskvthvmircqelkydvgggerfdsltdlvehyk
knpmvetlgtvlqlkqplnttrinaaeiesrvrelskgfweefetlqqqeckllysrkeg
qrqenknknrcknilpfdhtrvvlhdgdpnepvsdyinaniimpekksyiatqgclqntv
ndfwrmvfqensrvivmttkevergkskcvkywpdeyalkeygvmrvrnvkesaahdytl
relklskvgqgntertvwqyhfrtwpdhgvpsdpggvldfleevhhkqesimdagpvvvh
csagigrtgtfividilidiirekgvdcdidvpktiqmvrsqrsgmvqteaqyrfiymav
qhyietlqrrieeeqks

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4gwfB (B:)
mgsshhhhhhssgrenlyfqgmtsrrwfhpnitgveaenllltrgvdgsflarpsksnpg
dftlsvrrngavthikiqntgdyydlyggekfatlaelvqyymehhgqlkekngdvielk
yplncadptserwfhghlsgkeaeklltekgkhgsflvresqshpgdfvlsvrtgddkge
sndgkskvthvmircqelkydvgggerfdsltdlvehykknpmvetlgtvlqlkqplntt
rinaaeiesrvrelsklaettdkvkqgfweefetlqqqeckllysrkegqrqenknknrc
knilpfdhtrvvlhdgdpnepvsdyinaniimpefetkcnnskpkksyiatqgclqntvn
dfwrmvfqensrvivmttkevergkskcvkywpdeyalkeygvmrvrnvkesaahdytlr
elklskvgqgntertvwqyhfrtwpdhgvpsdpggvldfleevhhkqesimdagpvvvhc
sagigrtgtfividilidiirekgvdcdidvpktiqmvrsqrsgmvqteaqyrfiymavq
hyietlqrrieeeqkskrkg

    Sequence, based on observed residues (ATOM records): (download) 
    >4gwfB (B:)
srrwfhpnitgveaenllltrgvdgsflarpsksnpgdftlsvrrngavthikiqntgdy
ydlyggekfatlaelvqyymehhgqlvielkyplncadptserwfhghlsgkeaekllte
kgkhgsflvresqshpgdfvlsvrtgkvthvmircqelkydvgggerfdsltdlvehykk
npmvetlgtvlqlkqplnttrinaaeiesrvrelskgfweefetlqqqeckllysrkegq
rqenknknrcknilpfdhtrvvlhdgdpnepvsdyinaniimpksyiatqgclqntvndf
wrmvfqensrvivmttkevergkskcvkywpdeyalkeygvmrvrnvkesaahdytlrel
klskvgqgntertvwqyhfrtwpdhgvpsdpggvldfleevhhkqesimdagpvvvhcsa
gigrtgtfividilidiirekgvdcdidvpktiqmvrsqrsgmvqteaqyrfiymavqhy
ietlqrrieeeqk