PDB entry 4gum

View 4gum on RCSB PDB site
Description: Cystal structure of locked-trimer of human MIF
Class: isomerase
Keywords: alpha/beta mixture, cytokine and isomerase, isomerase
Deposited on 2012-08-29, released 2013-07-03
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-11-18, with a file datestamp of 2020-11-13.
Experiment type: XRAY
Resolution: 2.33 Å
R-factor: N/A
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: macrophage migration inhibitory factor
    Species: Homo sapiens [TaxId:9606]
    Gene: MIF, GLIF, MMIF
    Database cross-references and differences (RAF-indexed):
    • Uniprot P14174 (0-113)
      • engineered mutation (109)
    Domains in SCOPe 2.08: d4guma_
  • Chain 'B':
    Compound: macrophage migration inhibitory factor
    Species: Homo sapiens [TaxId:9606]
    Gene: MIF, GLIF, MMIF
    Database cross-references and differences (RAF-indexed):
    • Uniprot P14174 (0-113)
      • engineered mutation (109)
    Domains in SCOPe 2.08: d4gumb_
  • Chain 'C':
    Compound: macrophage migration inhibitory factor
    Species: Homo sapiens [TaxId:9606]
    Gene: MIF, GLIF, MMIF
    Database cross-references and differences (RAF-indexed):
    • Uniprot P14174 (0-113)
      • engineered mutation (109)
    Domains in SCOPe 2.08: d4gumc_
  • Chain 'D':
    Compound: macrophage migration inhibitory factor
    Species: Homo sapiens [TaxId:9606]
    Gene: MIF, GLIF, MMIF
    Database cross-references and differences (RAF-indexed):
    • Uniprot P14174 (0-113)
      • engineered mutation (109)
    Domains in SCOPe 2.08: d4gumd_
  • Chain 'E':
    Compound: macrophage migration inhibitory factor
    Species: Homo sapiens [TaxId:9606]
    Gene: MIF, GLIF, MMIF
    Database cross-references and differences (RAF-indexed):
    • Uniprot P14174 (0-113)
      • engineered mutation (109)
    Domains in SCOPe 2.08: d4gume_
  • Chain 'F':
    Compound: macrophage migration inhibitory factor
    Species: Homo sapiens [TaxId:9606]
    Gene: MIF, GLIF, MMIF
    Database cross-references and differences (RAF-indexed):
    • Uniprot P14174 (0-End)
      • engineered mutation (109)
    Domains in SCOPe 2.08: d4gumf_
  • Chain 'G':
    Compound: macrophage migration inhibitory factor
    Species: Homo sapiens [TaxId:9606]
    Gene: MIF, GLIF, MMIF
    Database cross-references and differences (RAF-indexed):
    • Uniprot P14174 (0-113)
      • engineered mutation (109)
    Domains in SCOPe 2.08: d4gumg_
  • Chain 'H':
    Compound: macrophage migration inhibitory factor
    Species: Homo sapiens [TaxId:9606]
    Gene: MIF, GLIF, MMIF
    Database cross-references and differences (RAF-indexed):
    • Uniprot P14174 (0-End)
      • engineered mutation (109)
    Domains in SCOPe 2.08: d4gumh_
  • Chain 'I':
    Compound: macrophage migration inhibitory factor
    Species: Homo sapiens [TaxId:9606]
    Gene: MIF, GLIF, MMIF
    Database cross-references and differences (RAF-indexed):
    • Uniprot P14174 (0-End)
      • engineered mutation (109)
    Domains in SCOPe 2.08: d4gumi_
  • Heterogens: CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4gumA (A:)
pmfivntnvprasvpdgflseltqqlaqatgkppqyiavhvvpdqlmafggssepcalcs
lhsigkiggaqnrsyskllcgllaerlrispdrvyinyydmnaanvgwncstfa

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4gumB (B:)
pmfivntnvprasvpdgflseltqqlaqatgkppqyiavhvvpdqlmafggssepcalcs
lhsigkiggaqnrsyskllcgllaerlrispdrvyinyydmnaanvgwncstfa

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4gumC (C:)
pmfivntnvprasvpdgflseltqqlaqatgkppqyiavhvvpdqlmafggssepcalcs
lhsigkiggaqnrsyskllcgllaerlrispdrvyinyydmnaanvgwncstfa

    Sequence, based on observed residues (ATOM records): (download) 
    >4gumC (C:)
pmfivntnvprasvpdgflseltqqlaqatgkppqyiavhvvpdqlmafggssepcalcs
lhsigggaqnrsyskllcgllaerlrispdrvyinyydmnaanvgwncstfa

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4gumD (D:)
pmfivntnvprasvpdgflseltqqlaqatgkppqyiavhvvpdqlmafggssepcalcs
lhsigkiggaqnrsyskllcgllaerlrispdrvyinyydmnaanvgwncstfa

    Sequence, based on observed residues (ATOM records): (download) 
    >4gumD (D:)
pmfivntnvprasvpdgflseltqqlaqatgkppqyiavhvvpdqlmafggssepcalcs
lhsigkiggaqnrsyskllcgllaerlrispdrvyinyydmngwncstfa

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >4gumE (E:)
pmfivntnvprasvpdgflseltqqlaqatgkppqyiavhvvpdqlmafggssepcalcs
lhsigkiggaqnrsyskllcgllaerlrispdrvyinyydmnaanvgwncstfa

    Sequence, based on observed residues (ATOM records): (download) 
    >4gumE (E:)
pmfivntnvprasvpdgflseltqqlaqatgkppqyiavhvvpdqlmafggssepcalcs
lhsigkaqnrsyskllcgllaerlrispdrvyinyydmnaanvgwncstfa

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >4gumF (F:)
pmfivntnvprasvpdgflseltqqlaqatgkppqyiavhvvpdqlmafggssepcalcs
lhsigkiggaqnrsyskllcgllaerlrispdrvyinyydmnaanvgwncstfa

    Sequence, based on observed residues (ATOM records): (download) 
    >4gumF (F:)
pmfivntnvprasvpdgflseltqqlaqatgkppqyiavhvvpdqlmafggssepcalcs
lhsigggaqnrsyskllcgllaerlrispdrvyinyydmnaanncstf

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >4gumG (G:)
pmfivntnvprasvpdgflseltqqlaqatgkppqyiavhvvpdqlmafggssepcalcs
lhsigkiggaqnrsyskllcgllaerlrispdrvyinyydmnaanvgwncstfa

    Sequence, based on observed residues (ATOM records): (download) 
    >4gumG (G:)
pmfivntnvprasvpdgflseltqqlaqatgkqyiavhvvpdqlmafggssepcalcslh
sigggaqnrsyskllcgllaerlrispdrvyinyydmnaanvgwncstfa

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >4gumH (H:)
pmfivntnvprasvpdgflseltqqlaqatgkppqyiavhvvpdqlmafggssepcalcs
lhsigkiggaqnrsyskllcgllaerlrispdrvyinyydmnaanvgwncstfa

    Sequence, based on observed residues (ATOM records): (download) 
    >4gumH (H:)
pmfivntnvprasvpdgflseltqqlaqatgkppqyiavhvvpdqlmafggssepcalcs
lhsiiggaqnrsyskllcgllaerlrispdrvyinyydmcs

  • Chain 'I':
    Sequence, based on SEQRES records: (download) 
    >4gumI (I:)
pmfivntnvprasvpdgflseltqqlaqatgkppqyiavhvvpdqlmafggssepcalcs
lhsigkiggaqnrsyskllcgllaerlrispdrvyinyydmnaanvgwncstfa

    Sequence, based on observed residues (ATOM records): (download) 
    >4gumI (I:)
pmfivntnvprasvpdgflseltqqlaqatgkppqyiavhvvpdqlmafggssepcalcs
lhsigkiggaqnrsyskllcgllaerlrispdrvyinyydmnaanvgwncstf