PDB entry 4gte

View 4gte on RCSB PDB site
Description: T. Maritima FDTS (E144R mutant) with FAD and Folate
Class: transferase
Keywords: Flavin-dependent thymidylate synthase, TM0449, E144R mutant, Folate, TRANSFERASE
Deposited on 2012-08-28, released 2012-10-17
The last revision prior to the SCOPe 2.08 freeze date was dated 2012-10-17, with a file datestamp of 2012-10-12.
Experiment type: XRAY
Resolution: 1.89 Å
R-factor: 0.185
AEROSPACI score: 0.49 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Thymidylate synthase thyX
    Species: Thermotoga maritima [TaxId:243274]
    Gene: thyX, thy1, TM_0449
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9WYT0 (12-End)
      • expression tag (10-11)
      • engineered mutation (155)
    Domains in SCOPe 2.08: d4gtea1, d4gtea2
  • Chain 'B':
    Compound: Thymidylate synthase thyX
    Species: Thermotoga maritima [TaxId:243274]
    Gene: thyX, thy1, TM_0449
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9WYT0 (12-231)
      • expression tag (11)
      • engineered mutation (155)
    Domains in SCOPe 2.08: d4gteb1, d4gteb2
  • Chain 'C':
    Compound: Thymidylate synthase thyX
    Species: Thermotoga maritima [TaxId:243274]
    Gene: thyX, thy1, TM_0449
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9WYT0 (12-231)
      • engineered mutation (155)
    Domains in SCOPe 2.08: d4gtec_
  • Chain 'D':
    Compound: Thymidylate synthase thyX
    Species: Thermotoga maritima [TaxId:243274]
    Gene: thyX, thy1, TM_0449
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9WYT0 (12-End)
      • engineered mutation (155)
    Domains in SCOPe 2.08: d4gted_
  • Heterogens: FAD, MEF, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4gteA (A:)
mgsdkihhhhhhmkidildkgfvelvdvmgndlsavraarvsfdmglkdeerdrhlieyl
mkhghetpfehivftfhvkapifvarqwfrhriasynelsgrysklsyefyipsperleg
ykttippervtekiseivdkayrtyleliesgvprrvarivlplnlytrffwtvnarslm
nflnlradshaqweiqqyalaiarifkekcpwtfeaflkyaykgdilkevqv

    Sequence, based on observed residues (ATOM records): (download) 
    >4gteA (A:)
hhmkidildkgfvelvdvmgndlsavraarvsfdmeerdrhlieylmkhghetpfehivf
tfhvkapifvarqwfrhriasynelsgrysklsyefyipsperlegykttippervteki
seivdkayrtyleliesgvprrvarivlplnlytrffwtvnarslmnflnlradshaqwe
iqqyalaiarifkekcpwtfeaflkyaykgdilke

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4gteB (B:)
mgsdkihhhhhhmkidildkgfvelvdvmgndlsavraarvsfdmglkdeerdrhlieyl
mkhghetpfehivftfhvkapifvarqwfrhriasynelsgrysklsyefyipsperleg
ykttippervtekiseivdkayrtyleliesgvprrvarivlplnlytrffwtvnarslm
nflnlradshaqweiqqyalaiarifkekcpwtfeaflkyaykgdilkevqv

    Sequence, based on observed residues (ATOM records): (download) 
    >4gteB (B:)
hmkidildkgfvelvdvmgndlsavraarvsfdeerdrhlieylmkhghetpfehivftf
hvkapifvarqwfrhriasynelsgrylsyefyipsperlegykttippervtekiseiv
dkayrtyleliesgvprrvarivlplnlytrffwtvnarslmnflnlradshaqweiqqy
alaiarifkekcpwtfeaflkyaykgdilkevqv

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4gteC (C:)
mgsdkihhhhhhmkidildkgfvelvdvmgndlsavraarvsfdmglkdeerdrhlieyl
mkhghetpfehivftfhvkapifvarqwfrhriasynelsgrysklsyefyipsperleg
ykttippervtekiseivdkayrtyleliesgvprrvarivlplnlytrffwtvnarslm
nflnlradshaqweiqqyalaiarifkekcpwtfeaflkyaykgdilkevqv

    Sequence, based on observed residues (ATOM records): (download) 
    >4gteC (C:)
mkidildkgfvelvdvmgndlsavraarvsfdkdeerdrhlieylmkhghetpfehivft
fhvkapifvarqwfrhriasynelsgrysklsyefyipsperlegykttippervtekis
eivdkayrtyleliesgvprrvarivlplnlytrffwtvnarslmnflnlradshaqwei
qqyalaiarifkekcpwtfeaflkyaykgdilkevqv

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4gteD (D:)
mgsdkihhhhhhmkidildkgfvelvdvmgndlsavraarvsfdmglkdeerdrhlieyl
mkhghetpfehivftfhvkapifvarqwfrhriasynelsgrysklsyefyipsperleg
ykttippervtekiseivdkayrtyleliesgvprrvarivlplnlytrffwtvnarslm
nflnlradshaqweiqqyalaiarifkekcpwtfeaflkyaykgdilkevqv

    Sequence, based on observed residues (ATOM records): (download) 
    >4gteD (D:)
mkidildkgfvelvdvmgndlsavraarvsfddeerdrhlieylmkhghetpfehivftf
hvkapifvarqwfrhriasynelsgrysklsyefyipsperlegykttippervtekise
ivdkayrtyleliesgvprrvarivlplnlytrffwtvnarslmnflnlradshaqweiq
qyalaiarifkekcpwtfeaflkyaykgdilkev