PDB entry 4gtd

View 4gtd on RCSB PDB site
Description: T. Maritima FDTS (E144R mutant) with FAD and dUMP
Class: transferase
Keywords: Flavin-dependent thymidylate synthase, TM0449, E144R mutant, TRANSFERASE
Deposited on 2012-08-28, released 2012-10-17
The last revision prior to the SCOPe 2.08 freeze date was dated 2012-10-17, with a file datestamp of 2012-10-12.
Experiment type: XRAY
Resolution: 1.76 Å
R-factor: 0.181
AEROSPACI score: 0.53 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Thymidylate synthase thyX
    Species: Thermotoga maritima [TaxId:243274]
    Gene: thyX, thy1, TM_0449
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9WYT0 (12-End)
      • expression tag (10-11)
      • engineered mutation (155)
    Domains in SCOPe 2.08: d4gtda1, d4gtda2
  • Chain 'B':
    Compound: Thymidylate synthase thyX
    Species: Thermotoga maritima [TaxId:243274]
    Gene: thyX, thy1, TM_0449
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9WYT0 (12-231)
      • expression tag (11)
      • engineered mutation (155)
    Domains in SCOPe 2.08: d4gtdb1, d4gtdb2
  • Chain 'C':
    Compound: Thymidylate synthase thyX
    Species: Thermotoga maritima [TaxId:243274]
    Gene: thyX, thy1, TM_0449
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9WYT0 (12-231)
      • engineered mutation (155)
    Domains in SCOPe 2.08: d4gtdc_
  • Chain 'D':
    Compound: Thymidylate synthase thyX
    Species: Thermotoga maritima [TaxId:243274]
    Gene: thyX, thy1, TM_0449
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9WYT0 (12-End)
      • expression tag (11)
      • engineered mutation (155)
    Domains in SCOPe 2.08: d4gtdd1, d4gtdd2
  • Heterogens: UMP, FAD, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4gtdA (A:)
mgsdkihhhhhhmkidildkgfvelvdvmgndlsavraarvsfdmglkdeerdrhlieyl
mkhghetpfehivftfhvkapifvarqwfrhriasynelsgrysklsyefyipsperleg
ykttippervtekiseivdkayrtyleliesgvprrvarivlplnlytrffwtvnarslm
nflnlradshaqweiqqyalaiarifkekcpwtfeaflkyaykgdilkevqv

    Sequence, based on observed residues (ATOM records): (download) 
    >4gtdA (A:)
hhmkidildkgfvelvdvmgndlsavraarvsfdmeerdrhlieylmkhghetpfehivf
tfhvkapifvarqwfrhriasynelslsyefyipsperlegykttippervtekiseivd
kayrtyleliesgvprrvarivlplnlytrffwtvnarslmnflnlradshaqweiqqya
laiarifkekcpwtfeaflkyaykgdilke

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4gtdB (B:)
mgsdkihhhhhhmkidildkgfvelvdvmgndlsavraarvsfdmglkdeerdrhlieyl
mkhghetpfehivftfhvkapifvarqwfrhriasynelsgrysklsyefyipsperleg
ykttippervtekiseivdkayrtyleliesgvprrvarivlplnlytrffwtvnarslm
nflnlradshaqweiqqyalaiarifkekcpwtfeaflkyaykgdilkevqv

    Sequence, based on observed residues (ATOM records): (download) 
    >4gtdB (B:)
hmkidildkgfvelvdvmgndlsavraarvsfdeerdrhlieylmkhghetpfehivftf
hvkapifvarqwfrhriasynelsgrylsyefyipsperlegykttippervtekiseiv
dkayrtyleliesgvprrvarivlplnlytrffwtvnarslmnflnlradshaqweiqqy
alaiarifkekcpwtfeaflkyaykgdilkevqv

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4gtdC (C:)
mgsdkihhhhhhmkidildkgfvelvdvmgndlsavraarvsfdmglkdeerdrhlieyl
mkhghetpfehivftfhvkapifvarqwfrhriasynelsgrysklsyefyipsperleg
ykttippervtekiseivdkayrtyleliesgvprrvarivlplnlytrffwtvnarslm
nflnlradshaqweiqqyalaiarifkekcpwtfeaflkyaykgdilkevqv

    Sequence, based on observed residues (ATOM records): (download) 
    >4gtdC (C:)
mkidildkgfvelvdvmgndlsavraarvsfdmglkdeerdrhlieylmkhghetpfehi
vftfhvkapifvarqwfrhriasynelsklsyefyipsperlegykttippervtekise
ivdkayrtyleliesgvprrvarivlplnlytrffwtvnarslmnflnlradshaqweiq
qyalaiarifkekcpwtfeaflkyaykgdilkevqv

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4gtdD (D:)
mgsdkihhhhhhmkidildkgfvelvdvmgndlsavraarvsfdmglkdeerdrhlieyl
mkhghetpfehivftfhvkapifvarqwfrhriasynelsgrysklsyefyipsperleg
ykttippervtekiseivdkayrtyleliesgvprrvarivlplnlytrffwtvnarslm
nflnlradshaqweiqqyalaiarifkekcpwtfeaflkyaykgdilkevqv

    Sequence, based on observed residues (ATOM records): (download) 
    >4gtdD (D:)
hmkidildkgfvelvdvmgndlsavraarvsfdkdeerdrhlieylmkhghetpfehivf
tfhvkapifvarqwfrhriasynelrysklsyefyipsperlegykttippervtekise
ivdkayrtyleliesgvprrvarivlplnlytrffwtvnarslmnflnlradshaqweiq
qyalaiarifkekcpwtfeaflkyaykgdil