PDB entry 4grw

View 4grw on RCSB PDB site
Description: Structure of a complex of human IL-23 with 3 Nanobodies (Llama vHHs)
Class: immune system
Keywords: Cytokine, immunoglobulin fold, VHH domain, IMMUNE SYSTEM
Deposited on 2012-08-27, released 2014-02-19
The last revision prior to the SCOPe 2.06 freeze date was dated 2014-04-16, with a file datestamp of 2014-04-11.
Experiment type: XRAY
Resolution: 2.55 Å
R-factor: 0.184
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Interleukin-23 subunit alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: IL23 p19, IL23A, SGRF, UNQ2498/PRO5798
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Interleukin-12 subunit beta
    Species: Homo sapiens [TaxId:9606]
    Gene: IL12 p40, IL12B, NKSF2
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Interleukin-23 subunit alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: IL23 p19, IL23A, SGRF, UNQ2498/PRO5798
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: Interleukin-12 subunit beta
    Species: Homo sapiens [TaxId:9606]
    Gene: IL12 p40, IL12B, NKSF2
    Database cross-references and differences (RAF-indexed):
  • Chain 'E':
    Compound: Nanobody 124C4
    Species: Lama glama [TaxId:9844]
    Database cross-references and differences (RAF-indexed):
    • PDB 4GRW (0-120)
    Domains in SCOPe 2.06: d4grwe_
  • Chain 'F':
    Compound: Nanobody 37D5
    Species: Lama glama [TaxId:9844]
    Database cross-references and differences (RAF-indexed):
    • PDB 4GRW (Start-125)
    Domains in SCOPe 2.06: d4grwf_
  • Chain 'G':
    Compound: Nanobody 124C4
    Species: Lama glama [TaxId:9844]
    Database cross-references and differences (RAF-indexed):
    • PDB 4GRW (0-124)
    Domains in SCOPe 2.06: d4grwg_
  • Chain 'H':
    Compound: Nanobody 22E11
    Species: Lama glama [TaxId:9844]
    Database cross-references and differences (RAF-indexed):
    • PDB 4GRW (0-122)
    Domains in SCOPe 2.06: d4grwh_
  • Chain 'I':
    Compound: Nanobody 22E11
    Species: Lama glama [TaxId:9844]
    Database cross-references and differences (RAF-indexed):
    • PDB 4GRW (0-122)
    Domains in SCOPe 2.06: d4grwi_
  • Chain 'J':
    Compound: Nanobody 37D5
    Species: Lama glama [TaxId:9844]
    Database cross-references and differences (RAF-indexed):
    • PDB 4GRW (Start-125)
    Domains in SCOPe 2.06: d4grwj_
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    No sequence available.

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    No sequence available.

  • Chain 'E':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4grwE (E:)
evqlvesggglvqpggslrlscaasgftlddyaiawfrqapgkeregvsgidsgdgsayy
adsvkgrftissdnakntvylqmnslrpedtavyycarvrtgwglnapdyamdywgkgtl
vtvss

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >4grwF (F:)
evqlvesggglvqpggslrlscaasgftldylaigwfrqapgkeregvscvsssgqytyy
adsvkgrftisrdnaestvylqmnslkpedtavyycatdpecyrvrgyyngeydywgqgt
qvtvss

    Sequence, based on observed residues (ATOM records): (download) 
    >4grwF (F:)
vqlvesggglvqpggslrlscaasgftldylaigwfrqapgkeregvscvsssgqytyya
dsvkgrftisrdnaestvylqmnslkpedtavyycatdpecyrvrgyyngeydywgqgtq
vtvss

  • Chain 'G':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4grwG (G:)
evqlvesggglvqpggslrlscaasgftlddyaiawfrqapgkeregvsgidsgdgsayy
adsvkgrftissdnakntvylqmnslrpedtavyycarvrtgwglnapdyamdywgkgtl
vtvss

  • Chain 'H':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4grwH (H:)
evqlvesggglvqaggslrlscaasgrtfswsavgwfrqapgkerefvaairwsggspyy
adsvkdrftisrdnakntvylqmnslrpedtavylcgetslfptsrgshydtwgqgtqvt
vss

  • Chain 'I':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4grwI (I:)
evqlvesggglvqaggslrlscaasgrtfswsavgwfrqapgkerefvaairwsggspyy
adsvkdrftisrdnakntvylqmnslrpedtavylcgetslfptsrgshydtwgqgtqvt
vss

  • Chain 'J':
    Sequence, based on SEQRES records: (download) 
    >4grwJ (J:)
evqlvesggglvqpggslrlscaasgftldylaigwfrqapgkeregvscvsssgqytyy
adsvkgrftisrdnaestvylqmnslkpedtavyycatdpecyrvrgyyngeydywgqgt
qvtvss

    Sequence, based on observed residues (ATOM records): (download) 
    >4grwJ (J:)
qlvesggglvqpggslrlscaasgftldylaigwfrqapgkeregvscvsssgqytyyad
svkgrftisrdnaestvylqmnslkpedtavyycatdpecyrvrgyyngdywgqgtqvtv
ss