PDB entry 4gqs
View 4gqs on RCSB PDB site
Description: Structure of Human Microsomal Cytochrome P450 (CYP) 2C19
Class: oxidoreductase
Keywords: monooxygenase, drug metabolizing enzyme, oxidoreductase, heme protein
Deposited on
2012-08-23, released
2012-11-14
The last revision prior to the SCOPe 2.02 freeze date was dated
2013-01-16, with a file datestamp of
2013-01-11.
Experiment type: XRAY
Resolution: 2.87 Å
R-factor: 0.25
AEROSPACI score: 0.21
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Cytochrome P450 2C19
Species: Homo sapiens [TaxId:9606]
Gene: CYP2C19
Database cross-references and differences (RAF-indexed):
- Chain 'B':
Compound: Cytochrome P450 2C19
Species: Homo sapiens [TaxId:9606]
Gene: CYP2C19
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.02: d4gqsb_ - Chain 'C':
Compound: Cytochrome P450 2C19
Species: Homo sapiens [TaxId:9606]
Gene: CYP2C19
Database cross-references and differences (RAF-indexed):
- Chain 'D':
Compound: Cytochrome P450 2C19
Species: Homo sapiens [TaxId:9606]
Gene: CYP2C19
Database cross-references and differences (RAF-indexed):
- Heterogens: HEM, 0XV, GOL, HOH
PDB Chain Sequences:
- Chain 'A':
No sequence available.
- Chain 'B':
Sequence, based on SEQRES records: (download)
>4gqsB (B:)
makktssgrgklppgptplpvignilqidikdvsksltnlskiygpvftlyfglermvvl
hgyevvkealidlgeefsgrghfplaeranrgfgivfsngkrwkeirrfslmtlrnfgmg
krsiedrvqeearclveelrktkaspcdptfilgcapcnvicsiifqkrfdykdqqflnl
meklnenirivstpwiqicnnfptiidyfpgthnkllknlafmesdilekvkehqesmdi
nnprdfidcflikmekekqnqqseftienlvitaadllgagtettsttlryalllllkhp
evtakvqeeiervvgrnrspcmqdrghmpytdavvhevqryidliptslphavtcdvkfr
nylipkgttiltsltsvlhdnkefpnpemfdprhfldeggnfkksnyfmpfsagkricvg
eglarmelflfltfilqnfnlkslidpkdldttpvvngfasvppfyqlcfipihhhh
Sequence, based on observed residues (ATOM records): (download)
>4gqsB (B:)
lppgptplpvignilqidikdvsksltnlskiygpvftlyfglermvvlhgyevvkeali
dlgeefsgrghfplaeranrgfgivfsngkrwkeirrfslmtlrnfgmgkrsiedrvqee
arclveelrktkaspcdptfilgcapcnvicsiifqkrfdykdqqflnlmeklneniriv
stpwiqicnnyfpgthnkllknlafmesdilekvkehqesmdinnprdfidcflikmeke
kqnqqseftienlvitaadllgagtettsttlryalllllkhpevtakvqeeiervvgrn
rspcmqdrghmpytdavvhevqryidliptslphavtcdvkfrnylipkgttiltsltsv
lhdnkefpnpemfdprhfldeggnfkksnyfmpfsagkricvgeglarmelflfltfilq
nfnlkslidpkdldttpvvngfasvppfyqlcfipi
- Chain 'C':
No sequence available.
- Chain 'D':
No sequence available.