PDB entry 4gql
View 4gql on RCSB PDB site
Description: Crystal structure of the catalytic domain of Human MMP12 in complex with selective phosphinic inhibitor RXP470.1
Class: hydrolase/hydrolase inhibitor
Keywords: potent selective phosphinic inhibitor, METZINCIN, Zinc protease, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on
2012-08-23, released
2013-02-06
The last revision prior to the SCOPe 2.08 freeze date was dated
2013-05-22, with a file datestamp of
2013-05-17.
Experiment type: XRAY
Resolution: 1.15 Å
R-factor: 0.134
AEROSPACI score: 0.87
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Macrophage metalloelastase
Species: Homo sapiens [TaxId:9606]
Gene: HME, MMP12
Database cross-references and differences (RAF-indexed):
- Uniprot P39900 (1-158)
- initiating methionine (0)
- engineered mutation (66)
Domains in SCOPe 2.08: d4gqla1, d4gqla2 - Heterogens: ZN, CA, R47, HOH