PDB entry 4gmy

View 4gmy on RCSB PDB site
Description: JAK2 kinase (JH1 domain) in complex with 2,6-DICHLORO-N-{2-[(CYCLOPROPYLCARBONYL)AMINO]PYRIDIN-4-YL}BENZAMIDE
Class: transferase/transferase inhibitor
Keywords: JAK2, JH1 kinase domain, Tyrosine kinase, phosphotransferase, phosphorylation, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2012-08-16, released 2013-06-19
The last revision prior to the SCOPe 2.03 freeze date was dated 2013-08-07, with a file datestamp of 2013-08-02.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: 0.167
AEROSPACI score: 0.39 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein kinase JAK2
    Species: Homo sapiens [TaxId:9606]
    Gene: JAK2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d4gmya_
  • Heterogens: 0X5, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4gmyA (A:)
gssgafedrdptqfeerhlkflqqlgkgnfgsvemcrydplqdntgevvavkklqhstee
hlrdfereieilkslqhdnivkykgvcysagrrnlklimeylpygslrdylqkhkeridh
ikllqytsqickgmeylgtkryihrdlatrnilvenenrvkigdfgltkvlpqdkeyykv
kepgespifwyapeslteskfsvasdvwsfgvvlyelftyieksksppaefmrmigndkq
gqmivfhliellknngrlprpdgcpdeiymimtecwnnnvnqrpsfrdlalrvdqirdnm
ag

    Sequence, based on observed residues (ATOM records): (download) 
    >4gmyA (A:)
sgafedrdptqfeerhlkflqqlgkgnfgsvemcrydplqdntgevvavkklqhsteehl
rdfereieilkslqhdnivkykgvcysagrrnlklimeylpygslrdylqkhkeridhik
llqytsqickgmeylgtkryihrdlatrnilvenenrvkigdfgltkvlpqdkeyykvke
pgespifwyapeslteskfsvasdvwsfgvvlyelftyieksksppaefmrmigndkqgq
mivfhliellknngrlprpdgcpdeiymimtecwnnnvnqrpsfrdlalrvdqirdnmag