PDB entry 4gmx

View 4gmx on RCSB PDB site
Description: Crystal structure of KPT185 in complex with CRM1-Ran-RanBP1
Class: protein transport/inhibitor
Keywords: HEAT repeat, protein export, CRM1, KPT185, nuclear, PROTEIN TRANSPORT-INHIBITOR complex
Deposited on 2012-08-16, released 2012-10-17
The last revision prior to the SCOPe 2.03 freeze date was dated 2012-12-12, with a file datestamp of 2012-12-07.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: 0.15
AEROSPACI score: 0.47 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: GTP-binding nuclear protein ran
    Species: Homo sapiens [TaxId:9606]
    Gene: RAN, ARA24, OK/SW-cl.81
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d4gmxa_
  • Chain 'B':
    Compound: Ran-specific GTPase-activating protein 1
    Species: Saccharomyces cerevisiae [TaxId:4932]
    Gene: YRB1, CST20, HTN1, SFO1, YDR002W, YD8119.08
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d4gmxb_
  • Chain 'C':
    Compound: Exportin-1
    Species: Saccharomyces cerevisiae [TaxId:4932]
    Gene: CRM1, KAP124, XPO1, YGR218W, G8514
    Database cross-references and differences (RAF-indexed):
    • Uniprot P30822 (2-End)
      • expression tag (0-1)
      • engineered mutation (540)
      • conflict (1023)
  • Heterogens: GNP, MG, EDO, K85, GOL, CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >4gmxA (A:)
    maaqgepqvqfklvlvgdggtgkttfvkrhltgefekkyvatlgvevhplvfhtnrgpik
    fnvwdtagqekfgglrdgyyiqaqcaiimfdvtsrvtyknvpnwhrdlvrvcenipivlc
    gnkvdikdrkvkaksivfhrkknlqyydisaksnynfekpflwlarkligdpnlefvamp
    alappevvmdpalaaqyehdlevaqttalpdedddl
    

    Sequence, based on observed residues (ATOM records): (download)
    >4gmxA (A:)
    qvqfklvlvgdggtgkttfvkrhltgefekkyvatlgvevhplvfhtnrgpikfnvwdta
    gqekfgglrdgyyiqaqcaiimfdvtsrvtyknvpnwhrdlvrvcenipivlcgnkvdik
    drkvkaksivfhrkknlqyydisaksnynfekpflwlarkligdpnlefvampalappev
    vlaaqyehdlevaqttalpdedddl
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >4gmxB (B:)
    sdihfepvvhlekvdvktmeedeevlykvraklfrfdadakewkergtgdckflknkktn
    kvrilmrrdktlkicanhiiapeytlkpnvgsdrswvyactadiaegeaeaftfairfgs
    kenadkfkeefekaqeinkka
    

    Sequence, based on observed residues (ATOM records): (download)
    >4gmxB (B:)
    tmeedeevlykvraklfrfdadakewkergtgdckflknkktnkvrilmrrdktlkican
    hiiapeytlkpnvgsdrswvyactadiaegeaeaftfairfgskenadkfkeefekaqei
    nkk
    

  • Chain 'C':
    No sequence available.