PDB entry 4gm8

View 4gm8 on RCSB PDB site
Description: Crystal structure of human WD repeat domain 5 with compound MM-102
Class: transcription/transcription inhibitor
Keywords: MLL1, histone methyltransferase, WD40, TRANSCRIPTION-TRANSCRIPTION INHIBITOR complex
Deposited on 2012-08-15, released 2013-07-31
The last revision prior to the SCOPe 2.07 freeze date was dated 2013-07-31, with a file datestamp of 2013-07-26.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: 0.195
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: WD repeat-containing protein 5
    Species: Homo sapiens [TaxId:9606]
    Gene: WDR5, BIG3
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4gm8a_
  • Chain 'B':
    Compound: WD repeat-containing protein 5
    Species: Homo sapiens [TaxId:9606]
    Gene: WDR5, BIG3
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4gm8b_
  • Chain 'C':
    Compound: WD repeat-containing protein 5
    Species: Homo sapiens [TaxId:9606]
    Gene: WDR5, BIG3
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4gm8c_
  • Chain 'D':
    Compound: WD repeat-containing protein 5
    Species: Homo sapiens [TaxId:9606]
    Gene: WDR5, BIG3
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4gm8d_
  • Chain 'E':
    Compound: mm-102
    Database cross-references and differences (RAF-indexed):
    • PDB 4GM8 (0-4)
  • Chain 'F':
    Compound: mm-102
    Database cross-references and differences (RAF-indexed):
    • PDB 4GM8 (0-4)
  • Chain 'G':
    Compound: mm-102
    Database cross-references and differences (RAF-indexed):
    • PDB 4GM8 (0-4)
  • Chain 'H':
    Compound: mm-102
    Database cross-references and differences (RAF-indexed):
    • PDB 4GM8 (0-4)
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4gm8A (A:)
satqskptpvkpnyalkftlaghtkavssvkfspngewlasssadklikiwgaydgkfek
tisghklgisdvawssdsnllvsasddktlkiwdvssgkclktlkghsnyvfccnfnpqs
nlivsgsfdesvriwdvktgkclktlpahsdpvsavhfnrdgslivsssydglcriwdta
sgqclktlidddnppvsfvkfspngkyilaatldntlklwdyskgkclktytghknekyc
ifanfsvtggkwivsgsednlvyiwnlqtkeivqklqghtdvvistachpteniiasaal
endktiklwksdc

    Sequence, based on observed residues (ATOM records): (download) 
    >4gm8A (A:)
vkpnyalkftlaghtkavssvkfspngewlasssadklikiwgaydgkfektisghklgi
sdvawssdsnllvsasddktlkiwdvssgkclktlkghsnyvfccnfnpqsnlivsgsfd
esvriwdvktgkclktlpahsdpvsavhfnrdgslivsssydglcriwdtasgqclktli
dnppvsfvkfspngkyilaatldntlklwdyskgkclktytghknekycifanfsvtggk
wivsgsednlvyiwnlqtkeivqklqghtdvvistachpteniiasaalendktiklwks
dc

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4gm8B (B:)
satqskptpvkpnyalkftlaghtkavssvkfspngewlasssadklikiwgaydgkfek
tisghklgisdvawssdsnllvsasddktlkiwdvssgkclktlkghsnyvfccnfnpqs
nlivsgsfdesvriwdvktgkclktlpahsdpvsavhfnrdgslivsssydglcriwdta
sgqclktlidddnppvsfvkfspngkyilaatldntlklwdyskgkclktytghknekyc
ifanfsvtggkwivsgsednlvyiwnlqtkeivqklqghtdvvistachpteniiasaal
endktiklwksdc

    Sequence, based on observed residues (ATOM records): (download) 
    >4gm8B (B:)
pnyalkftlaghtkavssvkfspngewlasssadklikiwgaydgkfektisghklgisd
vawssdsnllvsasddktlkiwdvssgkclktlkghsnyvfccnfnpqsnlivsgsfdes
vriwdvktgkclktlpahsdpvsavhfnrdgslivsssydglcriwdtasgqclktlidn
ppvsfvkfspngkyilaatldntlklwdyskgkclktytghknekycifanfsvtggkwi
vsgsednlvyiwnlqtkeivqklqghtdvvistachpteniiasaalendktiklwksdc

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4gm8C (C:)
satqskptpvkpnyalkftlaghtkavssvkfspngewlasssadklikiwgaydgkfek
tisghklgisdvawssdsnllvsasddktlkiwdvssgkclktlkghsnyvfccnfnpqs
nlivsgsfdesvriwdvktgkclktlpahsdpvsavhfnrdgslivsssydglcriwdta
sgqclktlidddnppvsfvkfspngkyilaatldntlklwdyskgkclktytghknekyc
ifanfsvtggkwivsgsednlvyiwnlqtkeivqklqghtdvvistachpteniiasaal
endktiklwksdc

    Sequence, based on observed residues (ATOM records): (download) 
    >4gm8C (C:)
vkpnyalkftlaghtkavssvkfspngewlasssadklikiwgaydgkfektisghklgi
sdvawssdsnllvsasddktlkiwdvssgkclktlkghsnyvfccnfnpqsnlivsgsfd
esvriwdvktgkclktlpahsdpvsavhfnrdgslivsssydglcriwdtasgqclktli
dnppvsfvkfspngkyilaatldntlklwdyskgkclktytghknekycifanfsvtggk
wivsgsednlvyiwnlqtkeivqklqghtdvvistachpteniiasaalendktiklwks
dc

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4gm8D (D:)
satqskptpvkpnyalkftlaghtkavssvkfspngewlasssadklikiwgaydgkfek
tisghklgisdvawssdsnllvsasddktlkiwdvssgkclktlkghsnyvfccnfnpqs
nlivsgsfdesvriwdvktgkclktlpahsdpvsavhfnrdgslivsssydglcriwdta
sgqclktlidddnppvsfvkfspngkyilaatldntlklwdyskgkclktytghknekyc
ifanfsvtggkwivsgsednlvyiwnlqtkeivqklqghtdvvistachpteniiasaal
endktiklwksdc

    Sequence, based on observed residues (ATOM records): (download) 
    >4gm8D (D:)
vkpnyalkftlaghtkavssvkfspngewlasssadklikiwgaydgkfektisghklgi
sdvawssdsnllvsasddktlkiwdvssgkclktlkghsnyvfccnfnpqsnlivsgsfd
esvriwdvktgkclktlpahsdpvsavhfnrdgslivsssydglcriwdtasgqclktli
ppvsfvkfspngkyilaatldntlklwdyskgkclktytghknekycifanfsvtggkwi
vsgsednlvyiwnlqtkeivqklqghtdvvistachpteniiasaalendktiklwksdc

  • Chain 'E':
    No sequence available.

  • Chain 'F':
    No sequence available.

  • Chain 'G':
    No sequence available.

  • Chain 'H':
    No sequence available.