PDB entry 4gj3

View 4gj3 on RCSB PDB site
Description: Tyk2 (JH1) in complex with 2,6-dichloro-4-cyano-N-[2-({[(1R,2R)-2-fluorocyclopropyl]carbonyl}amino)pyridin-4-yl]benzamide
Class: transferase/transferase inhibitor
Keywords: Kinase, ATP Binding, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2012-08-09, released 2013-05-29
The last revision prior to the SCOPe 2.08 freeze date was dated 2013-06-26, with a file datestamp of 2013-06-21.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: 0.212
AEROSPACI score: 0.33 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Non-receptor tyrosine-protein kinase TYK2
    Species: Homo sapiens [TaxId:9606]
    Gene: TYK2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P29597 (Start-294)
      • engineered mutation (54)
      • engineered mutation (87)
      • engineered mutation (89-90)
      • engineered mutation (141)
      • engineered mutation (260)
      • expression tag (295)
    Domains in SCOPe 2.08: d4gj3a1, d4gj3a2
  • Heterogens: 0XP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4gj3A (A:)
mgspasdptvfhkrylkkirdlgeghfgkvslycydptndgtgemvavkalkadagpqhr
sgwkqeidilrtlyhehiikykgccedagaaslqlvmeyvplgslrdylprhsiglaqll
lfaqqicegmaylhaqhyihrnlaarnvlldndrlvkigdfglakavpegheyyrvredg
dspvfwyapeclkeykfyyasdvwsfgvtlyellthcdssqspptkfleligiaqgqmtv
lrltellergerlprpdkcpaevyhlmkncweteasfrptfenlipilktvhekyrhhhh
hh

    Sequence, based on observed residues (ATOM records): (download) 
    >4gj3A (A:)
tvfhkrylkkirdlgeghfgkvslycydptndgtgemvavkalkadagpqhrsgwkqeid
ilrtlyhehiikykgccedagaaslqlvmeyvplgslrdylprhsiglaqlllfaqqice
gmaylhaqhyihrnlaarnvlldndrlvkigdfglakavpegheyyrvredgdspvfwya
peclkeykfyyasdvwsfgvtlyellthcdssqspptkfleligiaqgqmtvlrltelle
rgerlprpdkcpaevyhlmkncweteasfrptfenlipilktvhekyr