PDB entry 4gfn
View 4gfn on RCSB PDB site
Description: Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic
Class: Isomerase/Isomerase inhibitor
Keywords: ATP-binding, Nucleotide-binding, Topoisomerase, ATP-binding domain, DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, Isomerase-Isomerase inhibitor complex, cytosol
Deposited on
2012-08-03, released
2013-02-13
The last revision prior to the SCOPe 2.06 freeze date was dated
2013-02-27, with a file datestamp of
2013-02-22.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: 0.165
AEROSPACI score: 0.51
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: DNA gyrase subunit b
Species: Enterococcus faecalis [TaxId:226185]
Gene: EF_0005, gyrB
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.06: d4gfna1, d4gfna2 - Heterogens: SUY, GOL, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>4gfnA (A:)
gleavrkrpgmyigstsgeglhhlvweivdnsidealagfaksiqviiepddsitviddg
rgipvgiqaktgrpavetvftvlhaggkfggggykvsgglhgvgssvvnalstsldvrvy
kdgkvyyqeyrrgavvddlkvieetdrhgttvhfipdpeiftettvydfdklatrvrela
flnrglhisiedrregqedkkeyhyeglehhhhhh
Sequence, based on observed residues (ATOM records): (download)
>4gfnA (A:)
gleavrkrpgmyigstsgeglhhlvweivdnsidealagfaksiqviiepddsitviddg
rgipvgiqaktgrpavetvftvlhgvgssvvnalstsldvrvykdgkvyyqeyrrgavvd
dlkvieetdrhgttvhfipdpeiftettvydfdklatrvrelaflnrglhisiedrregq
edkkeyhyegleh