PDB entry 4gev

View 4gev on RCSB PDB site
Description: E. coli thymidylate synthase Y209W variant in complex with substrate and a cofactor analog
Class: transferase
Keywords: beta sheet, alpha/beta protein, methylase, TRANSFERASE
Deposited on 2012-08-02, released 2012-08-29
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-11-15, with a file datestamp of 2017-11-10.
Experiment type: XRAY
Resolution: 1.3 Å
R-factor: N/A
AEROSPACI score: 0.58 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Thymidylate synthase
    Species: Escherichia coli [TaxId:83333]
    Gene: b2827, JW2795, thyA
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0A884 (0-263)
      • engineered mutation (208)
    Domains in SCOPe 2.07: d4geva_
  • Chain 'B':
    Compound: Thymidylate synthase
    Species: Escherichia coli [TaxId:83333]
    Gene: b2827, JW2795, thyA
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0A884 (0-263)
      • engineered mutation (208)
    Domains in SCOPe 2.07: d4gevb_
  • Heterogens: UMC, CB3, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4gevA (A:)
mkqylelmqkvldegtqkndrtgtgtlsifghqmrfnlqdgfplvttkrchlrsiihell
wflqgdtniaylhennvtiwdewadengdlgpvygkqwrawptpdgrhidqittvlnqlk
ndpdsrriivsawnvgeldkmalapchaffqfyvadgklscqlyqrscdvflglpfnias
yallvhmmaqqcdlevgdfvwtggdthlwsnhmdqthlqlsreprplpkliikrkpesif
dyrfedfeiegydphpgikapvai

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4gevB (B:)
mkqylelmqkvldegtqkndrtgtgtlsifghqmrfnlqdgfplvttkrchlrsiihell
wflqgdtniaylhennvtiwdewadengdlgpvygkqwrawptpdgrhidqittvlnqlk
ndpdsrriivsawnvgeldkmalapchaffqfyvadgklscqlyqrscdvflglpfnias
yallvhmmaqqcdlevgdfvwtggdthlwsnhmdqthlqlsreprplpkliikrkpesif
dyrfedfeiegydphpgikapvai