PDB entry 4gc4

View 4gc4 on RCSB PDB site
Description: Crystal structure of the mutant R160A.R203A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP
Class: lyase/lyase inhibitor
Keywords: tim barrel, orotidine 5'-monophosphate decarboxylase, inhibitor BMP, LYASE-LYASE INHIBITOR complex
Deposited on 2012-07-29, released 2013-06-19
The last revision prior to the SCOPe 2.03 freeze date was dated 2013-06-19, with a file datestamp of 2013-06-14.
Experiment type: XRAY
Resolution: 1.42 Å
R-factor: 0.185
AEROSPACI score: 0.67 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: orotidine 5'-phosphate decarboxylase
    Species: Methanothermobacter thermautotrophicus str. Delta H [TaxId:187420]
    Gene: pyrF, MTH_129
    Database cross-references and differences (RAF-indexed):
    • Uniprot O26232
      • conflict (100)
      • engineered mutation (159)
      • engineered mutation (202)
    Domains in SCOPe 2.03: d4gc4a_
  • Chain 'B':
    Compound: orotidine 5'-phosphate decarboxylase
    Species: Methanothermobacter thermautotrophicus str. Delta H [TaxId:187420]
    Gene: pyrF, MTH_129
    Database cross-references and differences (RAF-indexed):
    • Uniprot O26232
      • conflict (100)
      • engineered mutation (159)
      • engineered mutation (202)
    Domains in SCOPe 2.03: d4gc4b_
  • Heterogens: BMP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4gc4A (A:)
mrsrrvdvmdvmnrlilamdlmnrddalrvtgevreyidtvkigyplvlsegmdiiaefr
krfgcriiadfkvadipetnekicratfkagadaiivhgfpgadsvraclnvaeemgrev
flltemshpgaemfiqgaadeiarmgvdlgvknyvgpstaperlsrlreiigqdsflisp
gvgaqggdpgetlrfadaiivgasiyladnpaaaaagiiesikdllnp

    Sequence, based on observed residues (ATOM records): (download) 
    >4gc4A (A:)
dvmdvmnrlilamdlmnrddalrvtgevreyidtvkigyplvlsegmdiiaefrkrfgcr
iiadfkvadipetnekicratfkagadaiivhgfpgadsvraclnvaeemgrevflltem
shpgaemfiqgaadeiarmgvdlgvknyvgpstaperlsrlreiigqdsflispgvgaqg
gdpgetlrfadaiivgasiyladnpaaaaagiiesikdl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4gc4B (B:)
mrsrrvdvmdvmnrlilamdlmnrddalrvtgevreyidtvkigyplvlsegmdiiaefr
krfgcriiadfkvadipetnekicratfkagadaiivhgfpgadsvraclnvaeemgrev
flltemshpgaemfiqgaadeiarmgvdlgvknyvgpstaperlsrlreiigqdsflisp
gvgaqggdpgetlrfadaiivgasiyladnpaaaaagiiesikdllnp

    Sequence, based on observed residues (ATOM records): (download) 
    >4gc4B (B:)
vdvmdvmnrlilamdlmnrddalrvtgevreyidtvkigyplvlsegmdiiaefrkrfgc
riiadfkvadipetnekicratfkagadaiivhgfpgadsvraclnvaeemgrevfllte
mshpgaemfiqgaadeiarmgvdlgvknyvgpstaperlsrlreiigqdsflispgvgaq
ggdpgetlrfadaiivgasiyladnpaaaaagiiesik