PDB entry 4gb2

View 4gb2 on RCSB PDB site
Description: HIV-1 protease (mutant Q7K L33I L63I) in complex with a bicyclic pyrrolidine inhibitor
Class: hydrolase/hydrolase inhibitor
Keywords: Dimer, ASPARTYL PROTEASE, INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 2012-07-26, released 2013-07-31
The last revision prior to the SCOPe 2.08 freeze date was dated 2013-07-31, with a file datestamp of 2013-07-26.
Experiment type: XRAY
Resolution: 1.79 Å
R-factor: 0.176
AEROSPACI score: 0.53 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Gag-Pol polyprotein
    Species: Human immunodeficiency virus type 1 (BRU ISOLATE) [TaxId:11686]
    Gene: gag-pol
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03367 (0-98)
      • engineered mutation (6)
      • engineered mutation (32)
      • engineered mutation (62)
    Domains in SCOPe 2.08: d4gb2a_
  • Chain 'B':
    Compound: Gag-Pol polyprotein
    Species: Human immunodeficiency virus type 1 (BRU ISOLATE) [TaxId:11686]
    Gene: gag-pol
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03367 (0-98)
      • engineered mutation (6)
      • engineered mutation (32)
      • engineered mutation (62)
    Domains in SCOPe 2.08: d4gb2b_
  • Heterogens: CL, GOL, 0LQ, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download)
    >4gb2A (A:)
    pqitlwkrplvtikiggqlkealldtgaddtvieemslpgrwkpkmiggiggfikvrqyd
    qiiieicghkaigtvlvgptpvniigrnlltqigctlnf
    

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download)
    >4gb2B (B:)
    pqitlwkrplvtikiggqlkealldtgaddtvieemslpgrwkpkmiggiggfikvrqyd
    qiiieicghkaigtvlvgptpvniigrnlltqigctlnf