PDB entry 4gaw

View 4gaw on RCSB PDB site
Description: Crystal structure of active human granzyme H
Class: hydrolase
Keywords: serine protease, Cytolysis, Hydrolase, cytotoxic granules
Deposited on 2012-07-25, released 2013-01-16
The last revision prior to the SCOPe 2.04 freeze date was dated 2013-07-17, with a file datestamp of 2013-07-12.
Experiment type: XRAY
Resolution: 3 Å
R-factor: 0.272
AEROSPACI score: 0.13 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Granzyme H
    Species: Homo sapiens [TaxId:9606]
    Gene: GZMH, CGL2, CTSGL2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d4gawa_
  • Chain 'B':
    Compound: Granzyme H
    Species: Homo sapiens [TaxId:9606]
    Gene: GZMH, CGL2, CTSGL2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d4gawb_
  • Chain 'C':
    Compound: Granzyme H
    Species: Homo sapiens [TaxId:9606]
    Gene: GZMH, CGL2, CTSGL2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d4gawc_
  • Chain 'D':
    Compound: Granzyme H
    Species: Homo sapiens [TaxId:9606]
    Gene: GZMH, CGL2, CTSGL2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d4gawd_
  • Chain 'E':
    Compound: Granzyme H
    Species: Homo sapiens [TaxId:9606]
    Gene: GZMH, CGL2, CTSGL2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d4gawe_
  • Chain 'F':
    Compound: Granzyme H
    Species: Homo sapiens [TaxId:9606]
    Gene: GZMH, CGL2, CTSGL2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d4gawf_
  • Chain 'G':
    Compound: Granzyme H
    Species: Homo sapiens [TaxId:9606]
    Gene: GZMH, CGL2, CTSGL2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d4gawg_
  • Chain 'H':
    Compound: Granzyme H
    Species: Homo sapiens [TaxId:9606]
    Gene: GZMH, CGL2, CTSGL2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d4gawh_
  • Chain 'I':
    Compound: Granzyme H
    Species: Homo sapiens [TaxId:9606]
    Gene: GZMH, CGL2, CTSGL2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d4gawi_
  • Chain 'J':
    Compound: Granzyme H
    Species: Homo sapiens [TaxId:9606]
    Gene: GZMH, CGL2, CTSGL2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d4gawj_
  • Chain 'K':
    Compound: Granzyme H
    Species: Homo sapiens [TaxId:9606]
    Gene: GZMH, CGL2, CTSGL2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d4gawk_
  • Chain 'L':
    Compound: Granzyme H
    Species: Homo sapiens [TaxId:9606]
    Gene: GZMH, CGL2, CTSGL2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d4gawl_
  • Heterogens: SO4, CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4gawA (A:)
iiggheakphsrpymafvqflqeksrkrcggilvrkdfvltaahcqgssinvtlgahnik
eqertqqfipvkrpiphpaynpknfsndimllqlerkakwttavrplrlpsskaqvkpgq
lcsvagwgyvsmstlattlqevlltvqkdcqcerlfhgnysrateicvgdpkktqtgfkg
dsggplvckdvaqgilsygnkkgtppgvyikvshflpwikrtmkrl

    Sequence, based on observed residues (ATOM records): (download) 
    >4gawA (A:)
iiggheakphsrpymafvqflqerkrcggilvrkdfvltaahcqgssinvtlgahnikeq
ertqqfipvkrpiphpaynpknfsndimllqlerkakwttavrplrlpsskaqvkpgqlc
svagwgyvsmstlattlqevlltvqkdcqcerlfhgnysrateicvgdpkktqtgfkgds
ggplvckdvaqgilsygnkkgtppgvyikvshflpwikrtmkrl

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4gawB (B:)
iiggheakphsrpymafvqflqeksrkrcggilvrkdfvltaahcqgssinvtlgahnik
eqertqqfipvkrpiphpaynpknfsndimllqlerkakwttavrplrlpsskaqvkpgq
lcsvagwgyvsmstlattlqevlltvqkdcqcerlfhgnysrateicvgdpkktqtgfkg
dsggplvckdvaqgilsygnkkgtppgvyikvshflpwikrtmkrl

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4gawC (C:)
iiggheakphsrpymafvqflqeksrkrcggilvrkdfvltaahcqgssinvtlgahnik
eqertqqfipvkrpiphpaynpknfsndimllqlerkakwttavrplrlpsskaqvkpgq
lcsvagwgyvsmstlattlqevlltvqkdcqcerlfhgnysrateicvgdpkktqtgfkg
dsggplvckdvaqgilsygnkkgtppgvyikvshflpwikrtmkrl

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4gawD (D:)
iiggheakphsrpymafvqflqeksrkrcggilvrkdfvltaahcqgssinvtlgahnik
eqertqqfipvkrpiphpaynpknfsndimllqlerkakwttavrplrlpsskaqvkpgq
lcsvagwgyvsmstlattlqevlltvqkdcqcerlfhgnysrateicvgdpkktqtgfkg
dsggplvckdvaqgilsygnkkgtppgvyikvshflpwikrtmkrl

  • Chain 'E':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4gawE (E:)
iiggheakphsrpymafvqflqeksrkrcggilvrkdfvltaahcqgssinvtlgahnik
eqertqqfipvkrpiphpaynpknfsndimllqlerkakwttavrplrlpsskaqvkpgq
lcsvagwgyvsmstlattlqevlltvqkdcqcerlfhgnysrateicvgdpkktqtgfkg
dsggplvckdvaqgilsygnkkgtppgvyikvshflpwikrtmkrl

  • Chain 'F':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4gawF (F:)
iiggheakphsrpymafvqflqeksrkrcggilvrkdfvltaahcqgssinvtlgahnik
eqertqqfipvkrpiphpaynpknfsndimllqlerkakwttavrplrlpsskaqvkpgq
lcsvagwgyvsmstlattlqevlltvqkdcqcerlfhgnysrateicvgdpkktqtgfkg
dsggplvckdvaqgilsygnkkgtppgvyikvshflpwikrtmkrl

  • Chain 'G':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4gawG (G:)
iiggheakphsrpymafvqflqeksrkrcggilvrkdfvltaahcqgssinvtlgahnik
eqertqqfipvkrpiphpaynpknfsndimllqlerkakwttavrplrlpsskaqvkpgq
lcsvagwgyvsmstlattlqevlltvqkdcqcerlfhgnysrateicvgdpkktqtgfkg
dsggplvckdvaqgilsygnkkgtppgvyikvshflpwikrtmkrl

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >4gawH (H:)
iiggheakphsrpymafvqflqeksrkrcggilvrkdfvltaahcqgssinvtlgahnik
eqertqqfipvkrpiphpaynpknfsndimllqlerkakwttavrplrlpsskaqvkpgq
lcsvagwgyvsmstlattlqevlltvqkdcqcerlfhgnysrateicvgdpkktqtgfkg
dsggplvckdvaqgilsygnkkgtppgvyikvshflpwikrtmkrl

    Sequence, based on observed residues (ATOM records): (download) 
    >4gawH (H:)
iiggheakphsrpymafvqflqeksrkrcggilvrkdfvltaahcqgssinvtlgahnik
eqertqqfipvkrpiphpaynpknfsndimllqlerkakwttavrplrlpkaqvkpgqlc
svagwgyvsmstlattlqevlltvqkdcqcerlnysrateicvgdpkktqtgfkgdsggp
lvckdvaqgilsygnkkgtppgvyikvshflpwikrtmkrl

  • Chain 'I':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4gawI (I:)
iiggheakphsrpymafvqflqeksrkrcggilvrkdfvltaahcqgssinvtlgahnik
eqertqqfipvkrpiphpaynpknfsndimllqlerkakwttavrplrlpsskaqvkpgq
lcsvagwgyvsmstlattlqevlltvqkdcqcerlfhgnysrateicvgdpkktqtgfkg
dsggplvckdvaqgilsygnkkgtppgvyikvshflpwikrtmkrl

  • Chain 'J':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4gawJ (J:)
iiggheakphsrpymafvqflqeksrkrcggilvrkdfvltaahcqgssinvtlgahnik
eqertqqfipvkrpiphpaynpknfsndimllqlerkakwttavrplrlpsskaqvkpgq
lcsvagwgyvsmstlattlqevlltvqkdcqcerlfhgnysrateicvgdpkktqtgfkg
dsggplvckdvaqgilsygnkkgtppgvyikvshflpwikrtmkrl

  • Chain 'K':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4gawK (K:)
iiggheakphsrpymafvqflqeksrkrcggilvrkdfvltaahcqgssinvtlgahnik
eqertqqfipvkrpiphpaynpknfsndimllqlerkakwttavrplrlpsskaqvkpgq
lcsvagwgyvsmstlattlqevlltvqkdcqcerlfhgnysrateicvgdpkktqtgfkg
dsggplvckdvaqgilsygnkkgtppgvyikvshflpwikrtmkrl

  • Chain 'L':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4gawL (L:)
iiggheakphsrpymafvqflqeksrkrcggilvrkdfvltaahcqgssinvtlgahnik
eqertqqfipvkrpiphpaynpknfsndimllqlerkakwttavrplrlpsskaqvkpgq
lcsvagwgyvsmstlattlqevlltvqkdcqcerlfhgnysrateicvgdpkktqtgfkg
dsggplvckdvaqgilsygnkkgtppgvyikvshflpwikrtmkrl