PDB entry 4gab

View 4gab on RCSB PDB site
Description: Human AKR1B10 mutant V301L complexed with NADP+ and fidarestat
Class: oxidoreductase
Keywords: tim barrel, aldo-keto reductase, oxidoreductase
Deposited on 2012-07-25, released 2013-03-20
The last revision prior to the SCOPe 2.06 freeze date was dated 2013-04-10, with a file datestamp of 2013-04-05.
Experiment type: XRAY
Resolution: 1.6 Å
R-factor: 0.176
AEROSPACI score: 0.6 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Aldo-keto reductase family 1 member B10
    Species: Homo sapiens [TaxId:9606]
    Gene: AKR1B10, AKR1B11
    Database cross-references and differences (RAF-indexed):
    • Uniprot O60218 (0-315)
      • engineered mutation (300)
    Domains in SCOPe 2.06: d4gaba_
  • Heterogens: NAP, FID, CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4gabA (A:)
matfvelstkakmpivglgtwksplgkvkeavkvaidagyrhidcayvyqnehevgeaiq
ekiqekavkredlfivsklwptfferplvrkafektlkdlklsyldvylihwpqgfksgd
dlfpkddkgnaiggkatfldaweameelvdeglvkalgvsnfshfqiekllnkpglkykp
vtnqvechpyltqekliqychskgitvtaysplgspdrpwakpedpslledpkikeiaak
hkktaaqvlirfhiqrnvivipksvtpariveniqvfdfklsdeematilsfnrnwracn
llqsshledypfnaey