PDB entry 4g8z

View 4g8z on RCSB PDB site
Description: pcDHFR K37S/F69N double mutant TMP NADPH ternary complex
Class: oxidoreductase/oxidoreductase inhibitor
Keywords: mutant pcDHFR inhibitor complex, TMP/NADPH ligands, K37S and F69N mutations, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex
Deposited on 2012-07-23, released 2013-05-29
The last revision prior to the SCOPe 2.08 freeze date was dated 2013-05-29, with a file datestamp of 2013-05-24.
Experiment type: XRAY
Resolution: 1.75 Å
R-factor: 0.261
AEROSPACI score: 0.42 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'X':
  Compound: dihydrofolate reductase
  Species: Pneumocystis jirovecii [TaxId:42068]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P16184 (0-203)
    • engineered mutation (34)
    • engineered mutation (66)
    • conflict (81-88)
  Domains in SCOPe 2.08: d4g8zx_
• Heterogens: TOP, NDP, HOH

PDB Chain Sequences:

• Chain 'X':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >4g8zX (X:)
  qqksltlivalttsygigrsnslpwklkkeisyfsrvtsfvptfdsfesmnvvlmgrktw
  esiplqnrplkgrinvvitrnaaaaaaaaihsaksldhalellyrtygsessvqinrifv
  iggaqlykaamdhpkldrimatiiykdihcdvffplkfrdkewssvwkkekhsdleswvg
  tkvphgkinedgfdyefemwtrdl