PDB entry 4g0n

View 4g0n on RCSB PDB site
Description: Crystal Structure of wt H-Ras-GppNHp bound to the RBD of Raf Kinase
Class: protein binding/transferase
Keywords: H-Ras, Ras, Raf kinase, Raf, GTPase, allosteric regulation, intrinsic hydrolysis, protein-protein interaction, Ras/Raf/MEK/ERK, kinase, GTP binding, PROTEIN BINDING-TRANSFERASE complex
Deposited on 2012-07-09, released 2013-07-17
The last revision prior to the SCOPe 2.05 freeze date was dated 2013-07-17, with a file datestamp of 2013-07-12.
Experiment type: XRAY
Resolution: 2.45 Å
R-factor: 0.186
AEROSPACI score: 0.35 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: gtpase hras
    Species: Homo sapiens [TaxId:9606]
    Gene: HRAS, HRAS1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d4g0na_
  • Chain 'B':
    Compound: raf proto-oncogene serine/threonine-protein kinase
    Species: Homo sapiens [TaxId:9606]
    Gene: RAF1, RAF
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d4g0nb_
  • Heterogens: GNP, CA, MG, ACT, DTU, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >4g0nA (A:)
    mteyklvvvgaggvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldildtag
    qeeysamrdqymrtgegflcvfainntksfedihqyreqikrvkdsddvpmvlvgnkcdl
    aartvesrqaqdlarsygipyietsaktrqgvedafytlvreirqh
    

    Sequence, based on observed residues (ATOM records): (download)
    >4g0nA (A:)
    mteyklvvvgaggvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldildtag
    qeeamrdqymrtgegflcvfainntksfedihqyreqikrvkdsddvpmvlvgnkcdlaa
    rtvesrqaqdlarsygipyietsaktrqgvedafytlvreirqh
    

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download)
    >4g0nB (B:)
    tsntirvflpnkqrtvvnvrngmslhdclmkalkvrglqpeccavfrllhehkgkkarld
    wntdaasligeelqvdfl