PDB entry 4g0n
View 4g0n on RCSB PDB site
Description: Crystal Structure of wt H-Ras-GppNHp bound to the RBD of Raf Kinase
Class: protein binding/transferase
Keywords: H-Ras, Ras, Raf kinase, Raf, GTPase, allosteric regulation, intrinsic hydrolysis, protein-protein interaction, Ras/Raf/MEK/ERK, kinase, GTP binding, PROTEIN BINDING-TRANSFERASE complex
Deposited on
2012-07-09, released
2013-07-17
The last revision prior to the SCOPe 2.08 freeze date was dated
2015-03-11, with a file datestamp of
2015-03-06.
Experiment type: XRAY
Resolution: 2.45 Å
R-factor: N/A
AEROSPACI score: 0.22
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: gtpase hras
Species: Homo sapiens [TaxId:9606]
Gene: HRAS, HRAS1
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d4g0na_ - Chain 'B':
Compound: raf proto-oncogene serine/threonine-protein kinase
Species: Homo sapiens [TaxId:9606]
Gene: RAF1, RAF
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d4g0nb_ - Heterogens: GNP, CA, MG, ACT, DTU, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>4g0nA (A:)
mteyklvvvgaggvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldildtag
qeeysamrdqymrtgegflcvfainntksfedihqyreqikrvkdsddvpmvlvgnkcdl
aartvesrqaqdlarsygipyietsaktrqgvedafytlvreirqh
Sequence, based on observed residues (ATOM records): (download)
>4g0nA (A:)
mteyklvvvgaggvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldildtag
qeeamrdqymrtgegflcvfainntksfedihqyreqikrvkdsddvpmvlvgnkcdlaa
rtvesrqaqdlarsygipyietsaktrqgvedafytlvreirqh
- Chain 'B':
Sequence; same for both SEQRES and ATOM records: (download)
>4g0nB (B:)
tsntirvflpnkqrtvvnvrngmslhdclmkalkvrglqpeccavfrllhehkgkkarld
wntdaasligeelqvdfl