PDB entry 4fz8

View 4fz8 on RCSB PDB site
Description: Crystal structure of C11 Fab, an ADCC mediating anti-HIV-1 antibody.
Class: immune system
Keywords: adcc, anti-hiv-1 env antibody c11, cd4i antibody, fab, viral glycoprotein gp120, hiv-1 env, immune system
Deposited on 2012-07-06, released 2013-07-10
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-05-19, with a file datestamp of 2021-05-14.
Experiment type: XRAY
Resolution: 2.66 Å
R-factor: N/A
AEROSPACI score: 0.17 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'H':
    Compound: FAB heavy chain of human ANTI-HIV-1 ENV ANTIBODY C11
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4FZ8 (0-End)
    Domains in SCOPe 2.08: d4fz8h_
  • Chain 'L':
    Compound: FAB light chain of human ANTI-HIV-1 ENV ANTIBODY C11
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4FZ8 (0-End)
    Domains in SCOPe 2.08: d4fz8l1, d4fz8l2
  • Heterogens: NAG, ZN, HOH

PDB Chain Sequences:

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >4fz8H (H:)
evqlvesggglvkpggslrlscaasgftfssysmnwvrqapgrglewvssisntstyiyy
adsvegrftlsrdnaknslylqmnslraedtavyycaranqhfdwllsllggyhyygmdv
wgqgttvtvssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsg
vhtfpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkrvepkscdkt

    Sequence, based on observed residues (ATOM records): (download) 
    >4fz8H (H:)
evqlvesggglvkpggslrlscaasgftfssysmnwvrqapgrglewvssisntstyiyy
adsvegrftlsrdnaknslylqmnslraedtavyycaranqhfdwllsllggyhyygmdv
wgqgttvtvssastkgpsvfgtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqss
glyslssvvtvpssslgtqtyicnvnhkpsntkvdkrvepks

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >4fz8L (L:)
divmtqsplslpvtpgepasiscrssqsllhsngynyldwylqkpgqspqlliylgsnra
sgvpdrfigsgsgtdftlkisrveaedvgvfycmqalqavgfgpgtkveikrtvaapsvf
ifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstysls
stltlskadyekhkvyacevthqglsspvtksfnrgec

    Sequence, based on observed residues (ATOM records): (download) 
    >4fz8L (L:)
divmtqsplslpvtpgepasiscrssqsllhsngynyldwylqkpgqspqlliylgsnra
sgvpdrfigsgsgtdftlkisrveaedvgvfycmqalqavgfgpgtkveikrtvaapsvf
ifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstysls
stltlskadyekhkvyacevthqglsspvtksfnr