PDB entry 4fz7
View 4fz7 on RCSB PDB site
Description: Crystal structure of spleen tyrosine kinase complexed with 6-((1R,2S)-2-Amino-cyclohexylamino)-4-(6-ethyl-pyridin-2-ylamino)-pyridazine-3-carboxylic acid amide
Class: transferase/transferase inhibitor
Keywords: kinase inhibitor, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on
2012-07-06, released
2013-07-10
The last revision prior to the SCOPe 2.06 freeze date was dated
2013-07-10, with a file datestamp of
2013-07-05.
Experiment type: XRAY
Resolution: 1.75 Å
R-factor: 0.202
AEROSPACI score: 0.5
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Tyrosine-protein kinase SYK
Species: Homo sapiens [TaxId:9606]
Gene: SYK
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.06: d4fz7a1, d4fz7a2 - Heterogens: 0VH, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>4fz7A (A:)
maleeirpkevyldrklltledkelgsgnfgtvkkgyyqmkkvvktvavkilkneandpa
lkdellaeanvmqqldnpyivrmigiceaeswmlvmemaelgplnkylqqnrhvkdknii
elvhqvsmgmkyleesnfvhrdlaarnvllvtqhyakisdfglskalradenyykaqthg
kwpvkwyapecinyykfssksdvwsfgvlmweafsygqkpyrgmkgsevtamlekgermg
cpagcpremydlmnlcwtydvenrpgfaavelrlrnyyydvvneghhhhhh
Sequence, based on observed residues (ATOM records): (download)
>4fz7A (A:)
vyldrklltledkelgsfgtvkkgyyqmkkvvktvavkilpalkdellaeanvmqqldnp
yivrmigiceaeswmlvmemaelgplnkylqqnrhvkdkniielvhqvsmgmkyleesnf
vhrdlaarnvllvtqhyakisdfglskalradenyykakwpvkwyapecinyykfssksd
vwsfgvlmweafsygqkpyrgmkgsevtamlekgermgcpagcpremydlmnlcwtydve
nrpgfaavelrlrnyyydvvneghh