PDB entry 4fz7

View 4fz7 on RCSB PDB site
Description: Crystal structure of spleen tyrosine kinase complexed with 6-((1R,2S)-2-Amino-cyclohexylamino)-4-(6-ethyl-pyridin-2-ylamino)-pyridazine-3-carboxylic acid amide
Class: transferase/transferase inhibitor
Keywords: kinase inhibitor, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2012-07-06, released 2013-07-10
The last revision prior to the SCOPe 2.07 freeze date was dated 2013-07-10, with a file datestamp of 2013-07-05.
Experiment type: XRAY
Resolution: 1.75 Å
R-factor: 0.202
AEROSPACI score: 0.5 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein kinase SYK
    Species: Homo sapiens [TaxId:9606]
    Gene: SYK
    Database cross-references and differences (RAF-indexed):
    • Uniprot P43405 (Start-282)
      • expression tag (283-286)
    Domains in SCOPe 2.07: d4fz7a1, d4fz7a2
  • Heterogens: 0VH, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >4fz7A (A:)
    maleeirpkevyldrklltledkelgsgnfgtvkkgyyqmkkvvktvavkilkneandpa
    lkdellaeanvmqqldnpyivrmigiceaeswmlvmemaelgplnkylqqnrhvkdknii
    elvhqvsmgmkyleesnfvhrdlaarnvllvtqhyakisdfglskalradenyykaqthg
    kwpvkwyapecinyykfssksdvwsfgvlmweafsygqkpyrgmkgsevtamlekgermg
    cpagcpremydlmnlcwtydvenrpgfaavelrlrnyyydvvneghhhhhh
    

    Sequence, based on observed residues (ATOM records): (download)
    >4fz7A (A:)
    vyldrklltledkelgsfgtvkkgyyqmkkvvktvavkilpalkdellaeanvmqqldnp
    yivrmigiceaeswmlvmemaelgplnkylqqnrhvkdkniielvhqvsmgmkyleesnf
    vhrdlaarnvllvtqhyakisdfglskalradenyykakwpvkwyapecinyykfssksd
    vwsfgvlmweafsygqkpyrgmkgsevtamlekgermgcpagcpremydlmnlcwtydve
    nrpgfaavelrlrnyyydvvneghh