PDB entry 4fqx

View 4fqx on RCSB PDB site
Description: Crystal structure of HLA-DM bound to HLA-DR1
Class: immune system
Keywords: immune complex, peptide loading, peptide editing, antigen presentation, IMMUNE SYSTEM
Deposited on 2012-06-25, released 2013-01-09
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-07-04.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: N/A
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: hla class II histocompatibility antigen, dr alpha chain
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-DR1 alpha chain, HLA-DRA, HLA-DRA1, MHC CLASS II MOLECULE
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01903
      • engineered mutation (64)
    Domains in SCOPe 2.08: d4fqxa1, d4fqxa2
  • Chain 'B':
    Compound: HLA class II histocompatibility antigen, DRB1-1 beta chain
    Species: Homo sapiens [TaxId:9606]
    Gene: beta chain, HLA-DR1, HLA-DRB1, MHC CLASS II MOLECULE
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04229 (6-End)
      • expression tag (0-5)
      • engineered mutation (35)
    Domains in SCOPe 2.08: d4fqxb1, d4fqxb2, d4fqxb3
  • Chain 'C':
    Compound: HLA class II histocompatibility antigen, DM alpha chain
    Species: Homo sapiens [TaxId:9606]
    Gene: DM alpha chain, DMA, HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, HLA-DMA, RING6
    Database cross-references and differences (RAF-indexed):
    • Uniprot P28067 (Start-198)
      • variant (135-136)
      • engineered mutation (164)
      • expression tag (199)
    Domains in SCOPe 2.08: d4fqxc1, d4fqxc2, d4fqxc3
  • Chain 'D':
    Compound: HLA class II histocompatibility antigen, DM beta chain
    Species: Homo sapiens [TaxId:9606]
    Gene: DM beta chain, DMB, HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, HLA-DMB, RING7
    Database cross-references and differences (RAF-indexed):
    • Uniprot P28068 (Start-192)
      • engineered mutation (45)
      • engineered mutation (91)
    Domains in SCOPe 2.08: d4fqxd1, d4fqxd2
  • Chain 'E':
    Compound: synthetic peptide
    Database cross-references and differences (RAF-indexed):
    • PDB 4FQX
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4fqxA (A:)
ikeehviiqaefylnpdqsgefmfdfdgdeifhvdmakketvwrleefgrfasfeaqgal
aniacdkanleimtkrsnytpitnvppevtvltnspvelrepnvlicfidkftppvvnvt
wlrngkpvttgvsetvflpredhlfrkfhylpflpstedvydcrvehwgldepllkhwef
dapsplpette

    Sequence, based on observed residues (ATOM records): (download) 
    >4fqxA (A:)
keehviiqaefylnpdqsgefmfdfdgdeifhvdmakketvwrleefgrfasfeaqgala
niacdkanleimtkrsnytpitnvppevtvltnspvelrepnvlicfidkftppvvnvtw
lrngkpvttgvsetvflpredhlfrkfhylpflpstedvydcrvehwgldepllkhwefd

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4fqxB (B:)
vlfqgpgdtrprflwqlkfechffngtervrllersiynqeesvrfdsdvgeyravtelg
rpdaeywnsqkdlleqrraavdtycrhnygvgesftvqrrvepkvtvypsktqplqhhnl
lvcsvsgfypgsievrwfrngqeekagvvstgliqngdwtfqtlvmletvprsgevytcq
vehpsvtspltvewrarssgggslpatg

    Sequence, based on observed residues (ATOM records): (download) 
    >4fqxB (B:)
vlfqgpgdtrprflwqlkfechffngtervrllersiynqeesvrfdsdvgeyravtelg
rpdaeywnsqkdlleqrraavdtycrhnygvgesftvqrrvepkvtvypsllvcsvsgfy
pgsievrwfrngqeekagvvstgliqngdwtfqtlvmletvprsgevytcqvehpsvtsp
ltvewra

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4fqxC (C:)
vpeaptpmwpddlqnhtflhtvycqdgspsvglseaydedqlfffdfsqntrvprlpefa
dwaqeqgdapailfdkefcewmiqqigpkldgkipvsrgfpiaevftlkplefgkpntlv
cfvsnlfppmltvnwqhhsvpvegfgptfvsavdglsfqafsyldftpepsdifscivth
eidrytaiaywvprnalpslvpr

    Sequence, based on observed residues (ATOM records): (download) 
    >4fqxC (C:)
nhtflhtvycqdgspsvglseaydedqlfffdfsqntrvprlpefadwaqeqgdapailf
dkefcewmiqqigpkldgkipvsrgfpiaevftlkplefgkpntlvcfvsnlfppmltvn
wqhhsvpvegfgptfvsavdglsfqafsyldftpepsdifscivtheidrytaiaywvpr
nalpsl

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4fqxD (D:)
ggfvahvestcllddagtpkdftycisfnkdlltcwdpeenkmapsefgvlnslanvlsq
hlnqkdtlmqrlrnglqncathtqpfwgsltdrtrppsvqvakttpfntrepvmlacyvw
gfypaevtitwrkngklvmphssahktaqpngdwtyqtlshlaltpsygdtytcvvehig
apepilrdwtpglgclvpr

    Sequence, based on observed residues (ATOM records): (download) 
    >4fqxD (D:)
fvahvestcllddagtpkdftycisfnkdlltcwdpeenkmapsefgvlnslanvlsqhl
nqkdtlmqrlrnglqncathtqpfwgsltdrtrppsvqvakttpfntrepvmlacyvwgf
ypaevtitwrkngklvmphssahktaqpngdwtyqtlshlaltpsygdtytcvvehigap
epilrdwtpgl

  • Chain 'E':
    No sequence available.