PDB entry 4fog

View 4fog on RCSB PDB site
Description: Crystal Structure of Mtb ThyA in Complex with 5-Fluoro-dUMP and 5-methyltetrahydrofolic acid
Class: transferase
Keywords: Structural Genomics, TB Structural Genomics Consortium, TBSGC, transferase, thymidylate synthase
Deposited on 2012-06-20, released 2013-08-07
The last revision prior to the SCOPe 2.08 freeze date was dated 2013-08-07, with a file datestamp of 2013-08-02.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: 0.214
AEROSPACI score: 0.32 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Thymidylate synthase
    Species: Mycobacterium tuberculosis [TaxId:83332]
    Gene: MT2834, MTV002.29c, Rv2764c, thyA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4foga_
  • Chain 'B':
    Compound: Thymidylate synthase
    Species: Mycobacterium tuberculosis [TaxId:83332]
    Gene: MT2834, MTV002.29c, Rv2764c, thyA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4fogb_
  • Chain 'C':
    Compound: Thymidylate synthase
    Species: Mycobacterium tuberculosis [TaxId:83332]
    Gene: MT2834, MTV002.29c, Rv2764c, thyA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4fogc_
  • Chain 'D':
    Compound: Thymidylate synthase
    Species: Mycobacterium tuberculosis [TaxId:83332]
    Gene: MT2834, MTV002.29c, Rv2764c, thyA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4fogd_
  • Heterogens: UFP, C2F, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4fogA (A:)
mtpyedllrfvletgtpksdrtgtgtrslfgqqmrydlsagfpllttkkvhfksvayell
wflrgdsnigwlhehgvtiwdewasdtgelgpiygvqwrswpapsgehidqisaaldllr
tdpdsrriivsawnvgeiermalppchaffqfyvadgrlscqlyqrsadlflgvpfnias
yallthmmaaqaglsvgefiwtggdchiydnhveqvrlqlsreprpypkllladrdsife
ytyedivvknydphpaikapvav

    Sequence, based on observed residues (ATOM records): (download) 
    >4fogA (A:)
mtpyedllrfvletgtpksdrtgtgtrslfgqqmrydlsagfpllttkkvhfksvayell
wflrgdsnigwlhehgvtiwdewasdtgelgpiygvqwrswpapsgehidqisaaldllr
tdpdsrriivsawnvgeiermalppchaffqfyvadgrlscqlyqrsadlflgvpfnias
yallthmmaaqaglsvgefiwtggdchiydnhveqvrlqlsreprpypkllladrdsife
ytyedivvknydphpaikap

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4fogB (B:)
mtpyedllrfvletgtpksdrtgtgtrslfgqqmrydlsagfpllttkkvhfksvayell
wflrgdsnigwlhehgvtiwdewasdtgelgpiygvqwrswpapsgehidqisaaldllr
tdpdsrriivsawnvgeiermalppchaffqfyvadgrlscqlyqrsadlflgvpfnias
yallthmmaaqaglsvgefiwtggdchiydnhveqvrlqlsreprpypkllladrdsife
ytyedivvknydphpaikapvav

    Sequence, based on observed residues (ATOM records): (download) 
    >4fogB (B:)
mtpyedllrfvletgtpksdgtgtrslfgqqmrydlsagfpllttkkvhfksvayellwf
lrgdsnigwlhehgvtiwdewasdtgelgpiygvqwrswpapsgehidqisaaldllrtd
pdsrriivsawnvgeiermalppchaffqfyvadgrlscqlyqrsadlflgvpfniasya
llthmmaaqaglsvgefiwtggdchiydnhveqvrlqlsreprpypkllladrdsifeyt
yedivvknydphpaikap

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4fogC (C:)
mtpyedllrfvletgtpksdrtgtgtrslfgqqmrydlsagfpllttkkvhfksvayell
wflrgdsnigwlhehgvtiwdewasdtgelgpiygvqwrswpapsgehidqisaaldllr
tdpdsrriivsawnvgeiermalppchaffqfyvadgrlscqlyqrsadlflgvpfnias
yallthmmaaqaglsvgefiwtggdchiydnhveqvrlqlsreprpypkllladrdsife
ytyedivvknydphpaikapvav

    Sequence, based on observed residues (ATOM records): (download) 
    >4fogC (C:)
mtpyedllrfvletgtpksdrtgtgtrslfgqqmrydlsagfpllttkkvhfksvayell
wflrgdsnigwlhehgvtiwdewasdtgelgpiygvqwrswpapsgehidqisaaldllr
tdpdsrriivsawnvgeiermalppchaffqfyvadgrlscqlyqrsadlflgvpfnias
yallthmmaaqaglsvgefiwtggdchiydnhveqvrlqlsreprpypkllladrdsife
ytyedivvknydphpaikapva

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4fogD (D:)
mtpyedllrfvletgtpksdrtgtgtrslfgqqmrydlsagfpllttkkvhfksvayell
wflrgdsnigwlhehgvtiwdewasdtgelgpiygvqwrswpapsgehidqisaaldllr
tdpdsrriivsawnvgeiermalppchaffqfyvadgrlscqlyqrsadlflgvpfnias
yallthmmaaqaglsvgefiwtggdchiydnhveqvrlqlsreprpypkllladrdsife
ytyedivvknydphpaikapvav