PDB entry 4fod

View 4fod on RCSB PDB site
Description: Crystal structure of human anaplastic lymphoma kinase in complex with acyliminobenzimidazole inhibitor 36
Class: Transferase/Inhibitor
Keywords: receptor tyrosine kinase, inhibitor, crizotinib, neuroblastoma, CD246, phosphotransferase, NPM-ALK, EML4-ALK, Transferase-Inhibitor complex
Deposited on 2012-06-20, released 2012-07-11
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-11-15, with a file datestamp of 2017-11-10.
Experiment type: XRAY
Resolution: 2 Å
R-factor: N/A
AEROSPACI score: 0.32 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: ALK tyrosine kinase receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: ALK
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9UM73
      • engineered mutation (19)
    Domains in SCOPe 2.08: d4foda_
  • Heterogens: 0UV, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4fodA (A:)
yklsklrtstimtdynpnysfagktssisdlkevprknitlirglghgafgevyegqvsg
mpndpsplqvavktlpevcseqdeldflmealiiskfnhqnivrcigvslqslprfille
lmaggdlksflretrprpsqpsslamldllhvardiacgcqyleenhfihrdiaarncll
tcpgpgrvakigdfgmardiyrasyyrkggcamlpvkwmppeafmegiftsktdtwsfgv
llweifslgympypsksnqevlefvtsggrmdppkncpgpvyrimtqcwqhqpedrpnfa
iilerieyctqdpdvintalpieygplveeeek

    Sequence, based on observed residues (ATOM records): (download) 
    >4fodA (A:)
tstimtdynpnysfagktssisdlkevprknitlirglghgafgevyegqvssplqvavk
tlpevcseqdeldflmealiiskfnhqnivrcigvslqslprfillelmaggdlksflre
trprpsqpsslamldllhvardiacgcqyleenhfihrdiaarnclltcpgpgrvakigd
fgmardiyracamlpvkwmppeafmegiftsktdtwsfgvllweifslgympypsksnqe
vlefvtsggrmdppkncpgpvyrimtqcwqhqpedrpnfaiilerieyctqdpdvintal
pieygplv