PDB entry 4foc

View 4foc on RCSB PDB site
Description: Crystal structure of human anaplastic lymphoma kinase in complex with acyliminobenzimidazole inhibitor 2
Class: Transferase/Inhibitor
Keywords: receptor tyrosine kinase, inhibitor, crizotinib, neuroblastoma, CD246, phosphotransferase, NPM-ALK, EML4-ALK, in situ proteolysis, Transferase-Inhibitor complex
Deposited on 2012-06-20, released 2012-07-11
The last revision prior to the SCOPe 2.05 freeze date was dated 2012-08-15, with a file datestamp of 2012-08-10.
Experiment type: XRAY
Resolution: 1.7 Å
R-factor: 0.191
AEROSPACI score: 0.55 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: ALK tyrosine kinase receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: ALK
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9UM73
      • engineered mutation (39)
    Domains in SCOPe 2.05: d4foca_
  • Heterogens: 0UU, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4focA (A:)
vyrrkhqelqamqmelqspeyklsklrtstimtdynpnysfagktssisdlkevprknit
lirglghgafgevyegqvsgmpndpsplqvavktlpevcseqdeldflmealiiskfnhq
nivrcigvslqslprfillelmaggdlksflretrprpsqpsslamldllhvardiacgc
qyleenhfihrdiaarnclltcpgpgrvakigdfgmardiyrasyyrkggcamlpvkwmp
peafmegiftsktdtwsfgvllweifslgympypsksnqevlefvtsggrmdppkncpgp
vyrimtqcwqhqpedrpnfaiilerieyctqdpdvintalpieygplveeeek

    Sequence, based on observed residues (ATOM records): (download) 
    >4focA (A:)
npnysfagktssisdlkevprknitlirglghgafgevyegqvssplqvavktlpevcse
qdeldflmealiiskfnhqnivrcigvslqslprfillelmaggdlksflretrprpsqp
sslamldllhvardiacgcqyleenhfihrdiaarnclltcpgpgrvakigdfgmardiy
rcamlpvkwmppeafmegiftsktdtwsfgvllweifslgympypsksnqevlefvtsgg
rmdppkncpgpvyrimtqcwqhqpedrpnfaiilerieyctqdpdvintalpieyg