PDB entry 4fnz
View 4fnz on RCSB PDB site
Description: Crystal structure of human anaplastic lymphoma kinase in complex with piperidine-carboxamide inhibitor 2
Class: Transferase/Inhibitor
Keywords: receptor tyrosine kinase, inhibitor, crizotinib, neuroblastoma, CD246, phosphotransferase, NPM-ALK, EML4-ALK, Transferase-Inhibitor complex
Deposited on
2012-06-20, released
2012-08-29
The last revision prior to the SCOPe 2.05 freeze date was dated
2012-11-14, with a file datestamp of
2012-11-09.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: 0.202
AEROSPACI score: 0.31
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: ALK tyrosine kinase receptor
Species: Homo sapiens [TaxId:9606]
Gene: ALK
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.05: d4fnza_ - Heterogens: NZF, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>4fnzA (A:)
rtstimtdynpnysfagktssisdlkevprknitlirglghgafgevyegqvsgmpndps
plqvavktlpevcseqdeldflmealiiskfnhqnivrcigvslqslprfillelmaggd
lksflretrprpsqpsslamldllhvardiacgcqyleenhfihrdiaarnclltcpgpg
rvakigdfgmardiyrasyyrkggcamlpvkwmppeafmegiftsktdtwsfgvllweif
slgympypsksnqevlefvtsggrmdppkncpgpvyrimtqcwqhqpedrpnfaiileri
eyctqdpdvintalpieygplveeeek
Sequence, based on observed residues (ATOM records): (download)
>4fnzA (A:)
npnysfagktssisdlkevprknitlirglghgevyegqvsgsplqvavktlpevcseqd
eldflmealiiskfnhqnivrcigvslqslprfillelmaggdlksflretrprpsqpss
lamldllhvardiacgcqyleenhfihrdiaarnclltcpgpgrvakigdfgcamlpvkw
mppeafmegiftsktdtwsfgvllweifslgympypsksnqevlefvtsggrmdppkncp
gpvyrimtqcwqhqpedrpnfaiilerieyctqdpdvintalpieyg