PDB entry 4fny

View 4fny on RCSB PDB site
Description: Crystal structure of the R1275Q anaplastic lymphoma kinase catalytic domain in complex with a benzoxazole inhibitor
Class: Transferase/Inhibitor
Keywords: receptor tyrosine kinase, inhibitor, crizotinib, neuroblastoma, CD246, phosphotransferase, NPM-ALK, EML4-ALK, Transferase-Inhibitor complex
Deposited on 2012-06-20, released 2012-08-29
The last revision prior to the SCOPe 2.03 freeze date was dated 2012-11-14, with a file datestamp of 2012-11-09.
Experiment type: XRAY
Resolution: 2.45 Å
R-factor: 0.196
AEROSPACI score: 0.34 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: ALK tyrosine kinase receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: ALK
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d4fnya_
  • Heterogens: I3K, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4fnyA (A:)
rtstimtdynpnysfagktssisdlkevprknitlirglghgafgevyegqvsgmpndps
plqvavktlpevcseqdeldflmealiiskfnhqnivrcigvslqslprfillelmaggd
lksflretrprpsqpsslamldllhvardiacgcqyleenhfihrdiaarnclltcpgpg
rvakigdfgmaqdiyrasyyrkggcamlpvkwmppeafmegiftsktdtwsfgvllweif
slgympypsksnqevlefvtsggrmdppkncpgpvyrimtqcwqhqpedrpnfaiileri
eyctqdpdvintalpieygplveeeek

    Sequence, based on observed residues (ATOM records): (download) 
    >4fnyA (A:)
ssisdlkevprknitlirglghgevyegqvsgplqvavktlpevcseqdeldflmealii
skfnhqnivrcigvslqslprfillelmaggdlksflretrprpslamldllhvardiac
gcqyleenhfihrdiaarnclltcpgpgrvakigdfcamlpvkwmppeafmegiftsktd
twsfgvllweifslgympypsksnqevlefvtsggrmdppkncpgpvyrimtqcwqhqpe
drpnfaiilerieyctqdpdvintalpieygpl