PDB entry 4fnx

View 4fnx on RCSB PDB site
Description: Crystal structure of the apo R1275Q anaplastic lymphoma kinase catalytic domain
Class: transferase
Keywords: receptor tyrosine kinase, inhibitor, crizotinib, neuroblastoma, CD246, phosphotransferase, NPM-ALK, EML4-ALK, TRANSFERASE
Deposited on 2012-06-20, released 2012-08-29
The last revision prior to the SCOPe 2.08 freeze date was dated 2012-11-14, with a file datestamp of 2012-11-09.
Experiment type: XRAY
Resolution: 1.7 Å
R-factor: 0.196
AEROSPACI score: 0.55 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: ALK tyrosine kinase receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: ALK
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9UM73
      • engineered mutation (13)
      • engineered mutation (191)
    Domains in SCOPe 2.08: d4fnxa_
  • Heterogens: GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4fnxA (A:)
rtstimtdynpnysfagktssisdlkevprknitlirglghgafgevyegqvsgmpndps
plqvavktlpevcseqdeldflmealiiskfnhqnivrcigvslqslprfillelmaggd
lksflretrprpsqpsslamldllhvardiacgcqyleenhfihrdiaarnclltcpgpg
rvakigdfgmaqdiyrasyyrkggcamlpvkwmppeafmegiftsktdtwsfgvllweif
slgympypsksnqevlefvtsggrmdppkncpgpvyrimtqcwqhqpedrpnfaiileri
eyctqdpdvintalpieygplveeeek

    Sequence, based on observed residues (ATOM records): (download) 
    >4fnxA (A:)
npnysfagktssisdlkevprknitlirglevyegqvspsplqvavktlpevcseqdeld
flmealiiskfnhqnivrcigvslqslprfillelmaggdlksflretrprpsqpsslam
ldllhvardiacgcqyleenhfihrdiaarnclltcpgpgrvakigdfgmaqdiycamlp
vkwmppeafmegiftsktdtwsfgvllweifslgympypsksnqevlefvtsggrmdppk
ncpgpvyrimtqcwqhqpedrpnfaiilerieyctqdpdvintalpieygpl