PDB entry 4fnw

View 4fnw on RCSB PDB site
Description: Crystal structure of the apo F1174L anaplastic lymphoma kinase catalytic domain
Class: transferase
Keywords: receptor tyrosine kinase, inhibitor, crizotinib, neuroblastoma, CD246, phosphotransferase, NPM-ALK, EML4-ALK, TRANSFERASE
Deposited on 2012-06-20, released 2012-08-29
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-11-15, with a file datestamp of 2017-11-10.
Experiment type: XRAY
Resolution: 1.75 Å
R-factor: N/A
AEROSPACI score: 0.39 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: ALK tyrosine kinase receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: ALK
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9UM73 (0-End)
      • engineered mutation (13)
      • engineered mutation (90)
    Domains in SCOPe 2.08: d4fnwa_
  • Heterogens: GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4fnwA (A:)
rtstimtdynpnysfagktssisdlkevprknitlirglghgafgevyegqvsgmpndps
plqvavktlpevcseqdeldflmealiisklnhqnivrcigvslqslprfillelmaggd
lksflretrprpsqpsslamldllhvardiacgcqyleenhfihrdiaarnclltcpgpg
rvakigdfgmardiyrasyyrkggcamlpvkwmppeafmegiftsktdtwsfgvllweif
slgympypsksnqevlefvtsggrmdppkncpgpvyrimtqcwqhqpedrpnfaiileri
eyctqdpdvintalpieygplveeeek

    Sequence, based on observed residues (ATOM records): (download) 
    >4fnwA (A:)
rtstimtdynpnysfagktssisdlkevprknitlirglggevyegqvssplqvavktlp
evcseqdeldflmealiisklnhqnivrcigvslqslprfillelmaggdlksflretrp
rpsqpsslamldllhvardiacgcqyleenhfihrdiaarnclltcpgpgrvakigdfgm
ardiyrcamlpvkwmppeafmegiftsktdtwsfgvllweifslgympypsksnqevlef
vtsggrmdppkncpgpvyrimtqcwqhqpedrpnfaiilerieyctqdpdvintalpiey
gplv