PDB entry 4flp
View 4flp on RCSB PDB site
Description: Crystal Structure of the first bromodomain of human BRDT in complex with the inhibitor JQ1
Class: transcription regulator/inhibitor
Keywords: BRDT, bromodomain containing protein testis specific, Nucleus, Transcription, Transcription regulation, Structural Genomics Consortium, SGC, Bromodomain, TRANSCRIPTION REGULATOR-INHIBITOR complex
Deposited on
2012-06-15, released
2012-07-11
The last revision prior to the SCOPe 2.04 freeze date was dated
2012-08-29, with a file datestamp of
2012-08-24.
Experiment type: XRAY
Resolution: 2.23 Å
R-factor: 0.213
AEROSPACI score: 0.37
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Bromodomain testis-specific protein
Species: Homo sapiens [TaxId:9606]
Gene: BRDT
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.04: d4flpa_ - Chain 'B':
Compound: Bromodomain testis-specific protein
Species: Homo sapiens [TaxId:9606]
Gene: BRDT
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.04: d4flpb_ - Heterogens: JQ1, K, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>4flpA (A:)
smntkkngrltnqlqylqkvvlkdlwkhsfswpfqrpvdavklqlpdyytiiknpmdlnt
ikkrlenkyyakaseciedfntmfsncylynkpgddivlmaqaleklfmqklsqmpqee
Sequence, based on observed residues (ATOM records): (download)
>4flpA (A:)
tnqlqylqkvvlkdlwkhsfswpfqrpvdavklqlpdyytiiknpmdlntikkrlenkyy
akaseciedfntmfsncylynkpgddivlmaqaleklfmqklsqmp
- Chain 'B':
Sequence, based on SEQRES records: (download)
>4flpB (B:)
smntkkngrltnqlqylqkvvlkdlwkhsfswpfqrpvdavklqlpdyytiiknpmdlnt
ikkrlenkyyakaseciedfntmfsncylynkpgddivlmaqaleklfmqklsqmpqee
Sequence, based on observed residues (ATOM records): (download)
>4flpB (B:)
tnqlqylqkvvlkdlwkhsfswpfqrpvdavklqlpdyytiiknpmdlntikkrlenkyy
akaseciedfntmfsncylynkpgddivlmaqaleklfmqklsqmpq