PDB entry 4fic

View 4fic on RCSB PDB site
Description: Kinase domain of cSrc in complex with a hinge region-binding fragment
Class: transferase/transferase inhibitor
Keywords: Hinge binding fragment, Type I, DFG-in, Tyrosine-protein kinase, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2012-06-08, released 2013-04-10
The last revision prior to the SCOPe 2.08 freeze date was dated 2013-06-19, with a file datestamp of 2013-06-14.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: 0.2
AEROSPACI score: 0.32 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Proto-oncogene tyrosine-protein kinase Src
    Species: Gallus gallus [TaxId:9031]
    Gene: SRC, v-Src
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4fica_
  • Chain 'B':
    Compound: Proto-oncogene tyrosine-protein kinase Src
    Species: Gallus gallus [TaxId:9031]
    Gene: SRC, v-Src
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4ficb_
  • Heterogens: 0UL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4ficA (A:)
ghmqtqglakdaweipreslrlevklgqgcfgevwmgtwngttrvaiktlkpgtmspeaf
lqeaqvmkklrheklvqlyavvseepiyivteymskgslldflkgemgkylrlpqlvdma
aqiasgmayvermnyvhrdlraanilvgenlvckvadfglarliedneytarqgakfpik
wtapeaalygrftiksdvwsfgilltelttkgrvpypgmvnrevldqvergyrmpcppec
peslhdlmcqcwrkdpeerptfeylqafledyftstepqyqpgenl

    Sequence, based on observed residues (ATOM records): (download) 
    >4ficA (A:)
lakdaweipreslrlevklgqgevwmgtwngttrvaiktlkplqeaqvmkklrheklvql
yavvseepiyivteymskgslldflkgemgkylrlpqlvdmaaqiasgmayvermnyvhr
dlraanilvgenlvckvadfgfpikwtapeaalygrftiksdvwsfgilltelttkgrvp
ypgmvnrevldqvergyrmpcppecpeslhdlmcqcwrkdpeerptfeylqafledyfts
tepqyqpgenl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4ficB (B:)
ghmqtqglakdaweipreslrlevklgqgcfgevwmgtwngttrvaiktlkpgtmspeaf
lqeaqvmkklrheklvqlyavvseepiyivteymskgslldflkgemgkylrlpqlvdma
aqiasgmayvermnyvhrdlraanilvgenlvckvadfglarliedneytarqgakfpik
wtapeaalygrftiksdvwsfgilltelttkgrvpypgmvnrevldqvergyrmpcppec
peslhdlmcqcwrkdpeerptfeylqafledyftstepqyqpgenl

    Sequence, based on observed residues (ATOM records): (download) 
    >4ficB (B:)
daweipreslrlevklgqgcfgevwmgtwngttrvaiktlqvmkklrheklvqlyavvse
epiyivteymskgslldflkgemgkylrlpqlvdmaaqiasgmayvermnyvhrdlraan
ilvgenlvckvadfgfpikwtapeaalygrftiksdvwsfgilltelttkgrvpypgmvn
revldqvergyrmpcppecpeslhdlmcqcwrkdpeerptfeylqafledyftstepqyq
pgenl