PDB entry 4fhk

View 4fhk on RCSB PDB site
Description: Crystal Structure of PI3K-gamma in Complex with Imidazopyridazine 19e
Class: Transferase/Transferase Inhibitor
Keywords: p110, kinase, ATP-binding, p84, p101, Transferase-Transferase Inhibitor complex
Deposited on 2012-06-06, released 2013-04-10
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-11-15, with a file datestamp of 2017-11-10.
Experiment type: XRAY
Resolution: 3 Å
R-factor: N/A
AEROSPACI score: 0.14 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
    Species: Homo sapiens [TaxId:9606]
    Gene: PIK3CG
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4fhka1, d4fhka2, d4fhka3, d4fhka4
  • Heterogens: SO4, 0U0, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4fhkA (A:)
gseesqafqrqltaligydvtdvsnvhddeleftrrglvtprmaevasrdpklyamhpwv
tskplpeylwkkianncifivihrsttsqtikvspddtpgailqsfftkmakkkslmdip
esqseqdfvlrvcgrdeylvgetpiknfqwvrhclkngeeihvvldtppdpaldevrkee
wplvddctgvtgyheqltihgkdhesvftvslwdcdrkfrvkirgidipvlprntdltvf
veaniqhgqqvlcqrrtspkpfteevlwnvwlefsikikdlpkgallnlqiycgkapals
skasaespsseskgkvqllyyvnlllidhrfllrrgeyvlhmwqisgkgedqgsfnadkl
tsatnpdkensmsisilldnychpialpkhqptpdpegdrvraempnqlrkqleaiiatd
plnpltaedkellwhfryeslkhpkaypklfssvkwgqqeivaktyqllarrevwdqsal
dvgltmqlldcnfsdenvraiavqklesledddvlhyllqlvqavkfepyhdsalarfll
krglrnkrighflfwflrseiaqsrhyqqrfavileaylrgcgtamlhdftqqvqvieml
qkvtldikslsaekydvssqvisqlkqklenlqnsqlpesfrvpydpglkagalaiekck
vmaskkkplwlefkcadptalsnetigiifkhgddlrqdmlilqilrimesiwetesldl
cllpygcistgdkigmieivkdattiakiqqstvgntgafkdevlnhwlkekspteekfq
aaverfvyscagycvatfvlgigdrhndnimitetgnlfhidfghilgnyksflginker
vpfvltpdflfvmgtsgkktsphfqkfqdicvkaylalrhhtnlliilfsmmlmtgmpql
tskedieyirdaltvgkneedakkyfldqievcrdkgwtvqfnwflhlvlgikqgekhsa

    Sequence, based on observed residues (ATOM records): (download) 
    >4fhkA (A:)
eesqafqrqltaligydvtdvsnvhddeleftrrglvtprmaevasrdpklyamhpwvts
kplpeylwkkianncifivihrsttsqtikvspddtpgailqsfftkmdfvlrvcgrdey
lvgetpiknfqwvrhclkngeeihvvldtppdpaldevrkecdrkfrvkirgidipvldl
tvfveaniqhgqqvlcqrrtspkpfteevlwnvwlefsikikdlpkgallnlqiycvqll
yyvnlllidhrfllrrgeyvlhmwqissfnadkltsatnpdkensmsisilldnempnql
rkqleaiiatdplnpltaedkellwhfryeslkhpkaypklfssvkwgqqeivaktyqll
arrevwdqsaldvgltmqlldcnfsdenvraiavqklesledddvlhyllqlvqavkfep
yhdsalarfllkrglrnkrighflfwflrseiaqsrhyqqrfavileaylrgcgtamlhd
ftqqvqviemlqkvtldikslkydvssqvisqlkqklenlqnsqlpesfrvpydpglkag
alaiekckvmaskkkplwlefkcadptalsnetigiifkhgddlrqdmlilqilrimesi
wetesldlcllpygcistgdkigmieivkdattiakiqqstvgnafkdevlnhwlkeksp
teekfqaaverfvyscagycvatfvlgigdrhndnimitetgnlfhidfghikervpfvl
tpdflfvmgtsktsphfqkfqdicvkaylalrhhtnlliilfsmmlmtgmskedieyird
altvgkneedakkyfldqievcrdkgwtvqfnwflhlvl