PDB entry 4fhb
View 4fhb on RCSB PDB site
Description: Enhancing DHFR catalysis by binding of an allosteric regulator nanobody (Nb179)
Class: Oxidoreductase/protein binding
Keywords: Nanobody, Dihydrofolate reductase, Allosteric activator, Reductase, Oxidoreductase-protein binding complex
Deposited on
2012-06-06, released
2013-04-24
The last revision prior to the SCOPe 2.05 freeze date was dated
2013-09-11, with a file datestamp of
2013-09-06.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: 0.221
AEROSPACI score: 0.26
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: dihydrofolate reductase
Species: Escherichia coli [TaxId:83333]
Gene: folA, tmrA, b0048, JW0047
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.05: d4fhba_ - Chain 'D':
Compound: Nb179
Species: Lama glama [TaxId:9844]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.05: d4fhbd_ - Heterogens: FOL, NAP
PDB Chain Sequences:
- Chain 'A':
Sequence; same for both SEQRES and ATOM records: (download)
>4fhbA (A:)
misliaalavdrvigmenampwnlpadlawfkrntlnkpvimgrhtwesigrplpgrkni
ilssqpgtddrvtwvksvdeaiaacgdvpeimvigggrvyeqflpkaqklylthidaeve
gdthfpdyepddwesvfsefhdadaqnshsycfeilerr
- Chain 'D':
Sequence, based on SEQRES records: (download)
>4fhbD (D:)
qvqlqesggglvqaggslrlsceasgrtfssyamgwfrqapgkerdfvaviswsgsntyy
adsakgrftisrdnakntvylqmnslkpedtaiyycaapgrphgsswslnkkgqgydywg
qgtqvtvsshhhhhh
Sequence, based on observed residues (ATOM records): (download)
>4fhbD (D:)
qlqesggglvqaggslrlsceasgrtfssyamgwfrqaperdfvaviswsgsntyyadsa
kgrftisrdnakntvylqmnslkpedtaiyycaapgrphgsswslnkkgqgydywgqgtq
vtvss