PDB entry 4fap

View 4fap on RCSB PDB site
Description: atomic structures of the rapamycin analogs in complex with both human fkbp12 and frb domain of frap
Class: cell cycle
Keywords: fkbp12, frap, rapamycin, complex, gene therapy
Deposited on 1999-05-06, released 2000-09-13
The last revision prior to the SCOP 1.75 freeze date was dated 2003-04-01, with a file datestamp of 2007-06-04.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: 0.184
AEROSPACI score: 0.37 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: fk506-binding protein
  Species: Homo sapiens
  Gene: HUMAN HIPPOCAMPAL CDNA LIBRARY SOURCE 8 (CLONTECH, PALO ALTO, CA)
  Database cross-references and differences (RAF-indexed):
  • Uniprot P62942 (0-106)
  Domains in SCOP 1.75: d4fapa_
• Chain 'B':
  Compound: fkbp12-rapamycin associated protein
  Species: HOMO SAPIENS
  Database cross-references and differences (RAF-indexed):
  • Uniprot P42345 (0-93)
  Domains in SCOP 1.75: d4fapb_
• Heterogens: ARD

PDB Chain Sequences:

• Chain 'A':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >4fapA (A:)
  gvqvetispgdgrtfpkrgqtcvvhytgmledgkkfdssrdrnkpfkfmlgkqevirgwe
  egvaqmsvgqrakltispdyaygatghpgiipphatlvfdvellkle
  

  
  
• Chain 'B':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >4fapB (B:)
  vailwhemwhegleeasrlyfgernvkgmfevleplhammergpqtlketsfnqaygrdl
  meaqewcrkymksgnvkdltqawdlyyhvfrris