PDB entry 4fal

View 4fal on RCSB PDB site
Description: Crystal structure of human 17beta-hydroxysteroid dehydrogenase type 5 in complex with 3-((3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)-N-methylbenzamide (80)
Class: oxidoreductase/oxidoreductase inhibitor
Keywords: aldo-keto reductase, oxidoreductase-oxidoreductase inhibitor complex
Deposited on 2012-05-22, released 2012-10-10
The last revision prior to the SCOPe 2.06 freeze date was dated 2012-10-10, with a file datestamp of 2012-10-05.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.184
AEROSPACI score: 0.47 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Aldo-keto reductase family 1 member C3
    Species: Homo sapiens [TaxId:9606]
    Gene: AKR1C3, DDH1, HSD17B5, KIAA0119, PGFS
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4fala_
  • Heterogens: NAP, 0T0, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4falA (A:)
mdskhqcvklndghfmpvlgfgtyappevprskalevtklaieagfrhidsahlynneeq
vglairskiadgsvkredifytsklwstfhrpelvrpalenslkkaqldyvdlylihspm
slkpgeelsptdengkvifdivdlcttweamekckdaglaksigvsnfnrrqlemilnkp
glkykpvcnqvechpyfnrsklldfckskdivlvaysalgsqrdkrwvdpnspvlledpv
lcalakkhkrtpalialryqlqrgvvvlaksyneqrirqnvqvfefqltaedmkaidgld
rnlhyfnsdsfashpnypysdeylehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4falA (A:)
hqcvklndghfmpvlgfgtyappevprskalevtklaieagfrhidsahlynneeqvgla
irskiadgsvkredifytsklwstfhrpelvrpalenslkkaqldyvdlylihspmslkp
ifdivdlcttweamekckdaglaksigvsnfnrrqlemilnkpglkykpvcnqvechpyf
nrsklldfckskdivlvaysalgsqrdkrwvdpnspvlledpvlcalakkhkrtpalial
ryqlqrgvvvlaksyneqrirqnvqvfefqltaedmkaidgldrnlhyfnsdsfashpny
pysdey