PDB entry 4f6h

View 4f6h on RCSB PDB site
Description: Mutagenesis of zinc ligand residue Cys221 reveals plasticity in the IMP-1 metallo-b-lactamase active site
Class: hydrolase
Keywords: metallo-b-lactamase, b-lactamase, HYDROLASE
Deposited on 2012-05-14, released 2013-03-27
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-06-30, with a file datestamp of 2021-06-25.
Experiment type: XRAY
Resolution: 1.74 Å
R-factor: N/A
AEROSPACI score: 0.47 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Beta-lactamase
    Species: Pseudomonas aeruginosa [TaxId:287]
    Gene: blaIMP-1, bla IMP, bla-imp, blaESP, imp
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q79MP6
      • engineered mutation (157)
      • expression tag (230-235)
    Domains in SCOPe 2.08: d4f6ha1, d4f6ha2
  • Heterogens: ZN, PO4, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4f6hA (A:)
aeslpdlkiekldegvyvhtsfeevngwgvvpkhglvvlvnaeaylidtpftakdteklv
twfvergykikgsisshfhsdstggiewlnsrsiptyaseltnellkkdgkvqatnsfsg
vnywlvknkievfypgpghtpdnvvvwlperkilfgggfikpyglgnlgdanieawpksa
kllkskygkaklvvpshsevgdasllkltleqavkglneskkpskpsnwshpqfek

    Sequence, based on observed residues (ATOM records): (download) 
    >4f6hA (A:)
lpdlkiekldegvyvhtsfeevngwgvvpkhglvvlvnaeaylidtpftakdteklvtwf
vergykikgsisshfhsdstggiewlnsrsiptyaseltnellkkdgkvqatnsfsgvny
wlvknkievfypgpghtpdnvvvwlperkilfgggfikpyglgnlgdanieawpksakll
kskygkaklvvpshsevgdasllkltleqavkglneshpqfek