PDB entry 4f45

View 4f45 on RCSB PDB site
Description: Crystal structure of human CD38 E226Q mutant in complex with NAADP
Class: hydrolase
Keywords: CD38, ADP-ribosyl cyclase, NAADP, Calcium signaling, HYDROLASE
Deposited on 2012-05-10, released 2013-04-03
The last revision prior to the SCOPe 2.07 freeze date was dated 2013-04-03, with a file datestamp of 2013-03-29.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: 0.173
AEROSPACI score: 0.45 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: ADP-ribosyl cyclase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: CD38
    Database cross-references and differences (RAF-indexed):
    • Uniprot P28907 (2-End)
      • expression tag (0-1)
      • engineered mutation (5)
      • engineered mutation (56)
      • engineered mutation (120)
      • engineered mutation (165)
      • engineered mutation (175)
      • engineered mutation (182)
    Domains in SCOPe 2.07: d4f45a1, d4f45a2
  • Chain 'B':
    Compound: ADP-ribosyl cyclase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: CD38
    Database cross-references and differences (RAF-indexed):
    • Uniprot P28907 (2-End)
      • expression tag (1)
      • engineered mutation (5)
      • engineered mutation (56)
      • engineered mutation (120)
      • engineered mutation (165)
      • engineered mutation (175)
      • engineered mutation (182)
    Domains in SCOPe 2.07: d4f45b1, d4f45b2
  • Heterogens: DN4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4f45A (A:)
efwrqtwsgpgttkrfpetvlarcvkyteihpemrhvdcqsvwdafkgafiskhpcdite
edyqplmklgtqtvpcnkillwsrikdlahqftqvqrdmftledtllgyladdltwcgef
dtskinyqscpdwrkdcsnnpvsvfwktvsrrfaeaacdvvhvmldgsrskifdkdstfg
svqvhnlqpekvqtleawvihggredsrdlcqdptikelesiiskrniqfsckniyrpdk
flqcvknpedssctsei

    Sequence, based on observed residues (ATOM records): (download) 
    >4f45A (A:)
efwrqtwsgpgttkrfpetvlarcvkyteihpemrhvdcqsvwdafkgafiskhpcdite
edyqplmklgtqtvpcnkillwsrikdlahqftqvqrdmftledtllgyladdltwcgef
dtskinyqscpdwrkdcsnnpvsvfwktvsrrfaeaacdvvhvmldgsrskifdkdstfg
svqvhnlqpekvqtleawvihggrdlcqdptikelesiiskrniqfsckniyrpdkflqc
vknpedssc

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4f45B (B:)
efwrqtwsgpgttkrfpetvlarcvkyteihpemrhvdcqsvwdafkgafiskhpcdite
edyqplmklgtqtvpcnkillwsrikdlahqftqvqrdmftledtllgyladdltwcgef
dtskinyqscpdwrkdcsnnpvsvfwktvsrrfaeaacdvvhvmldgsrskifdkdstfg
svqvhnlqpekvqtleawvihggredsrdlcqdptikelesiiskrniqfsckniyrpdk
flqcvknpedssctsei

    Sequence, based on observed residues (ATOM records): (download) 
    >4f45B (B:)
fwrqtwsgpgttkrfpetvlarcvkyteihpemrhvdcqsvwdafkgafiskhpcditee
dyqplmklgtqtvpcnkillwsrikdlahqftqvqrdmftledtllgyladdltwcgefd
tskinyqscpdwrkdcsnnpvsvfwktvsrrfaeaacdvvhvmldgsrskifdkdstfgs
vqvhnlqpekvqtleawvihgrdlcqdptikelesiiskrniqfsckniyrpdkflqcvk
npedssc